Yu Hua-Xiang, Rui Hai-Ying, Han Zi-Qi, Li Ruo-Chuan, Liu Lu-Lu, Xue Li, Chen Yu-Guo
Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine,Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province,Key Laboratory of Emergency and Critical Care Medicine of Shandong Province,Institute of Emergency and Critical Care Medicine of Shandong University,Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine,Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University,Jinan 250012,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Aug;44(4):661-667. doi: 10.3881/j.issn.1000-503X.13745.
As a DNA receptor in the cytoplasm,cyclic GMP-AMP synthase (cGAS) can recognize abnormal DNA in the cytoplasm and activate stimulator of interferon genes (STING) to regulate the immune response. The recent studies have demonstrated that this pathway plays a role in non-infectious inflammatory diseases by promoting the expression of type Ⅰ interferon and interferon-stimulated gene.This article reviews the activation and regulation of cGAS-STING pathway in multiple systems and the effect of this pathway on the occurrence and progression of non-infectious inflammatory diseases,providing theoretical reference for future application of cGAS-STING pathway-related drugs in non-infectious inflammatory diseases.
作为细胞质中的一种DNA受体，环状GMP-AMP合酶（cGAS）能够识别细胞质中的异常DNA并激活干扰素基因刺激因子（STING），从而调节免疫反应。最近的研究表明，该信号通路通过促进Ⅰ型干扰素和干扰素刺激基因的表达，在非感染性炎症性疾病中发挥作用。本文综述了cGAS-STING信号通路在多个系统中的激活与调控，以及该信号通路对非感染性炎症性疾病发生发展的影响，为cGAS-STING信号通路相关药物未来在非感染性炎症性疾病中的应用提供理论参考。
