Qian J H, Ye L, Tan Y
Department of Respiratory and Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2024 Mar 12;47(3):252-258. doi: 10.3760/cma.j.cn112147-20231020-00251.
Cyclic GMP-AMP synthase (cGAS) is a DNA receptor that produces the second messenger cyclic GMP-AMP (cGAMP). cGAMP activates stimulator of interferon genes (STING), which initiates a signaling cascade leading to immune and inflammatory responses. This intricate molecular pathway plays a pivotal role in the pathogenesis and progression of diverse respiratory ailments, including respiratory infection, lung cancer, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, asthma, and acute lung injury. Consequently, the cGAS-STING signaling pathway has emerged as a promising novel therapeutic target, opening up new avenues for the diagnosis and treatment of respiratory disorders. This review focuses on recent advances in our understanding of the cGAS-STING signaling pathway and its intricate involvement in respiratory system diseases.
环鸟苷酸-腺苷酸合成酶（cGAS）是一种产生第二信使环鸟苷酸-腺苷酸（cGAMP）的DNA受体。cGAMP激活干扰素基因刺激因子（STING），后者启动导致免疫和炎症反应的信号级联反应。这一复杂的分子途径在多种呼吸系统疾病的发病机制和进展中起关键作用，包括呼吸道感染、肺癌、特发性肺纤维化、慢性阻塞性肺疾病、哮喘和急性肺损伤。因此，cGAS-STING信号通路已成为一个有前景的新型治疗靶点，为呼吸系统疾病的诊断和治疗开辟了新途径。本综述重点关注我们对cGAS-STING信号通路的最新认识进展及其在呼吸系统疾病中的复杂参与情况。
