Zhou Chun-Hong, Lu Zi-Bin
Third Grade Research Laboratory of State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Aug;44(4):693-698. doi: 10.3881/j.issn.1000-503X.13975.
Circular RNAs (circRNAs),a group of highly conserved small RNAs,are characterized by a closed circular structure from precursor linear RNA through reverse splicing.They are powerful regulators of the physiological and pathological processes in organisms at different development stages.Zebrafish can be used for the high-throughput drug screening with low cost.Thus,the circRNAs associated with development and inflammation can be mined from zebrafish.Recently,a variety of circRNAs in zebrafish have been identified and characterized.Studies have proved that circRNAs play a vital role in the development and inflammation of zebrafish.The paper summarizes the classification,characteristics,and biological functions of circRNAs,and reviews the research progress in zebrafish's circRNAs.
环状RNA（circRNAs）是一类高度保守的小RNA，其特征是通过反向剪接从前体线性RNA形成封闭的环状结构。它们是生物体在不同发育阶段生理和病理过程的强大调节因子。斑马鱼可用于低成本的高通量药物筛选。因此，可以从斑马鱼中挖掘与发育和炎症相关的circRNAs。最近，已经鉴定并表征了斑马鱼中的多种circRNAs。研究证明，circRNAs在斑马鱼的发育和炎症中起着至关重要的作用。本文总结了circRNAs的分类、特征和生物学功能，并综述了斑马鱼circRNAs的研究进展。
