State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin, 300071, P. R. China.
Adv Healthc Mater. 2022 Nov;11(22):e2201611. doi: 10.1002/adhm.202201611. Epub 2022 Sep 13.
Reversibly controlling the dye arrangements in living systems has great potential to realize spatiotemporally controlled photomedicine. However, tuning or even maintaining a certain arrangement of dyes in a complex living environments is extremely challenging due to the interference of the various biological species. Herein, a conceptual supramolecular strategy to engineer a switchable photosensitizer (PS) via mitochondria-mediated dynamic interconversion between monomer and J-aggregation, enabling specific activation of the mitochondria-targeting photodynamic therapy (PDT) and hibernation after mitochondria damage is presented. The presented mitochondria-mediated "activate-then-hibernate" PS design enables a fascinating spatiotemporally controlled PDT in which spatially controlled mitochondrial-targeting enhances therapeutic efficacy and temporally controlled activation-then-hibernation averts off-target damage during PDT and tissue damage after clinical treatment, thus offering significant potential for biological research and clinical needs.
在活系统中可逆地控制染料排列，对于实现时空可控的光医学具有巨大的潜力。然而，由于各种生物物种的干扰，在复杂的生活环境中调整甚至维持染料的某种排列是极其具有挑战性的。在此，通过线粒体介导的单体和 J-聚集体之间的动态互变，设计了一种用于构建可切换光敏剂（PS）的概念性超分子策略，从而实现了线粒体靶向光动力疗法（PDT）的特异性激活和线粒体损伤后的休眠。所提出的线粒体介导的“激活-然后休眠”PS 设计实现了一种引人入胜的时空可控 PDT，其中空间控制的线粒体靶向增强了治疗效果，而时间控制的激活-然后休眠避免了 PDT 期间的非靶向损伤和临床治疗后的组织损伤，从而为生物研究和临床需求提供了重要的潜力。
