Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.
Institute of Stroke Research, Soochow University, Suzhou, China.
CNS Neurosci Ther. 2022 Dec;28(12):1930-1941. doi: 10.1111/cns.13966. Epub 2022 Sep 6.
Glioma is characterized as the most aggressive brain tumor that occurred in the central nervous system. The circadian rhythm is an essential cyclic change system generated by the endogenous circadian clock. Current studies found that the circadian clock affects glioma pathophysiology. It is still controversial whether the circadian rhythm disruption is a cause or an effect of tumorigenesis. This review discussed the association between cell cycle and circadian clock and provided a prominent molecular theoretical basis for tumor therapy. We illustrated the external factors affecting the circadian clock including thermodynamics, hypoxia, post-translation, and microRNA, while the internal characteristics concerning the circadian clock in glioma involve stemness, metabolism, radiotherapy sensitivity, and chemotherapy sensitivity. We also summarized the molecular pathways and the therapeutic drugs involved in the glioma circadian rhythm. There are still many questions in this field waiting for further investigation. The results of glioma chronotherapy in sensitizing radiation therapy and chemotherapy have shown great therapeutic potential in improving clinical outcomes. These findings will help us further understand the characteristics of glioma pathophysiology.
神经胶质瘤的特征是中枢神经系统中最具侵袭性的脑肿瘤。昼夜节律是由内源性生物钟产生的重要周期性变化系统。目前的研究发现，生物钟会影响神经胶质瘤的病理生理学。昼夜节律紊乱是肿瘤发生的原因还是结果仍存在争议。本综述讨论了细胞周期与生物钟之间的联系，并为肿瘤治疗提供了突出的分子理论基础。我们阐述了影响生物钟的外部因素，包括热力学、缺氧、翻译后修饰和 microRNA，而与神经胶质瘤中生物钟相关的内部特征包括干性、代谢、放疗敏感性和化疗敏感性。我们还总结了昼夜节律相关的分子途径和治疗药物。该领域仍有许多问题有待进一步研究。神经胶质瘤的chronotherapy 在提高放疗和化疗敏感性方面显示出了巨大的治疗潜力，改善了临床结局。这些发现将帮助我们进一步了解神经胶质瘤病理生理学的特征。
