Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Department of Biomedical Sciences, QU-Health, College of Health Sciences, Qatar University, Doha, Qatar.
Aging Male. 2022 Dec;25(1):234-241. doi: 10.1080/13685538.2022.2118253.
Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as hesitancy, intermittency, weak stream, nocturia, urine frequency, and urgency. Additionally, LUTS (obstructive or irritative symptoms) are common in elderly men with hypogonadism, identified as the reduced testes capability in producing sex steroids and sperm, and are categorized as testosterone deficiency. Even though the mode of action (MoA) of testosterone therapy (TTh) on hypogonadal men needs more researched and understanding, the effectiveness of TTh in the development of male genital organs has been reported in several studies. This review shows the latest updates of TTh in LUTS including potential adverse effects, advantages, and disadvantages.
下尿路症状（LUTS）是由膀胱颈部张力升高（纤维化或僵硬所致）或良性前列腺增生引起的，这两种情况都会导致膀胱出口的静态阻塞。这两种形式都会引起一组症状，如犹豫、间歇性、弱流、夜尿、尿频和尿急。此外，低睾丸激素症的老年男性中常见 LUTS（梗阻或刺激性症状），低睾丸激素症被定义为睾丸产生性激素和精子的能力下降，并被归类为睾丸激素缺乏症。尽管睾丸激素治疗（TTh）对低睾丸激素症男性的作用机制（MoA）需要更多的研究和理解，但 TTh 在男性生殖器发育中的有效性已在几项研究中得到报道。这篇综述展示了 TTh 在 LUTS 中的最新进展，包括潜在的不良反应、优点和缺点。
