The Interrelationship Between Andropause Symptoms, Testosterone Levels, and Lower Urinary Tract Symptoms in Men With Benign Prostatic Hyperplasia (BPH): A Cross-Sectional Study.

Introduction This study aimed to assess the prevalence of andropause symptoms and testosterone levels in male patients with symptomatic benign prostatic hyperplasia (BPH), as well as to explore the relationship between these factors. Methods A total of 183 male patients aged 50 years and older with diagnosed lower urinary tract symptoms (LUTS) due to BPH were included. Andropause symptoms were evaluated using the Male Andropause Symptoms Self-Assessment Questionnaire (MASSQ), while testosterone levels were measured using a chemiluminescent immunoassay. LUTS severity was assessed through the International Prostate Symptom Score (IPSS) and erectile function via the International Index of Erectile Function-15 (IIEF-15). However, the cross-sectional design and it being conducted in a single center limit the study. Results The mean andropause symptom score was 57.24 ± 12.62, indicating moderate to severe symptoms. A significant correlation was observed between increasing lower urinary tract symptom (LUTS) severity and higher andropause symptom scores (p < 0.001). Testosterone levels were significantly lower in patients with severe LUTS (285.94 ± 106.9 ng/dL) compared to those with mild LUTS (544.09 ± 109.8 ng/dL). Additionally, comorbidities such as diabetes mellitus and hypertension were associated with increased severity of both LUTS and erectile dysfunction (ED). Conclusions The study highlights a significant prevalence of andropause symptoms in men with BPH, emphasizing the correlation between declining testosterone levels and LUTS severity. These findings underscore the importance of comprehensive assessments and management strategies that address both hormonal deficiencies and urinary health in older men.