镉抑制培养的大鼠肝实质细胞的蛋白质分泌。
Cadmium inhibits protein secretion from cultured rat liver parenchymal cells.
作者信息
Mitane Y, Aoki Y, Suzuki K T
出版信息
Biochem Pharmacol. 1987 Aug 15;36(16):2647-52. doi: 10.1016/0006-2952(87)90546-6.
Depressive action of cadmium (Cd) to the protein secretion from liver was studied in vitro using primary cultures of rat liver parenchymal cells. The cells were cultured in the presence of 0.1-5 microM cadmium chloride. Over this concentration range Cd had no effect on protein synthesis, but caused a dose-dependent inhibition of protein secretion. Although the metallothionein level was increased more than 4-fold by incubation with 10(-6) M dexamethasone, the depressive action of Cd was not prevented by the induction of metallothionein.
利用大鼠肝实质细胞原代培养物在体外研究了镉（Cd）对肝脏蛋白质分泌的抑制作用。细胞在含有0.1 - 5微摩尔氯化镉的条件下培养。在此浓度范围内，镉对蛋白质合成没有影响，但会导致蛋白质分泌呈剂量依赖性抑制。尽管通过与10⁻⁶ M地塞米松孵育，金属硫蛋白水平增加了4倍以上，但镉的抑制作用并未因金属硫蛋白的诱导而受到阻止。
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