Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
J Gastroenterol Hepatol. 2022 Nov;37(11):2039-2050. doi: 10.1111/jgh.15999. Epub 2022 Sep 20.
Hepatocellular carcinoma (HCC) is the most common liver malignancy that can be developed from hepatitis B and cirrhosis. Many pathophysiological alterations, including hepatitis B virus (HBV) DNA integration, oxidative stress, cytokine release, telomerase homeostasis, mitochondrial damage, epigenetic modification, and tumor microenvironment, are involved in the biological process from hepatitis B to cirrhosis and HCC. N6-methyladenosine (m6A), as an epitranscriptomic modification of RNAs, can regulate the stability, splicing, degradation, transcription, and translation of downstream target RNAs in HBV and liver cancer cells. m6A regulators (writers, erasers, and readers) play an important role in the pathogenesis of HBV-associated HCC by regulating cell proliferation, apoptosis, migration, autophagy, differentiation, inflammation, angiogenesis, and tumor microenvironment. This review summarizes the current progress of m6A methylation in the molecular mechanisms, biological functions, and potential clinical implications of HBV-associated HCC.
肝细胞癌（HCC）是最常见的肝脏恶性肿瘤，可由乙型肝炎和肝硬化发展而来。许多病理生理改变，包括乙型肝炎病毒（HBV）DNA 整合、氧化应激、细胞因子释放、端粒酶稳态、线粒体损伤、表观遗传修饰和肿瘤微环境，参与了从乙型肝炎到肝硬化和 HCC 的生物学过程。N6-甲基腺苷（m6A）作为 RNA 的转录后修饰，可以调节 HBV 和肝癌细胞下游靶 RNA 的稳定性、剪接、降解、转录和翻译。m6A 调节因子（writers、erasers 和 readers）通过调节细胞增殖、凋亡、迁移、自噬、分化、炎症、血管生成和肿瘤微环境，在 HBV 相关 HCC 的发病机制中发挥重要作用。本综述总结了 m6A 甲基化在 HBV 相关 HCC 的分子机制、生物学功能和潜在临床意义方面的最新进展。
