Qian Weiwei, Zhou Jian, Duan Ligeng, Wang Haoyu, Xu Shuyun, Cao Yu
Department of Emergency Medicine, Laboratory of Emergency Medicine, West China Hospital, and Disaster Medical Center, Sichuan University, Chengdu, 610044, Sichuan, China.
Department of Emergency,Shangjinnanfu Hospital, West China Hospital, Sichuan University, Chengdu, 610044, Sichuan, China.
Cell Death Discov. 2023 Aug 18;9(1):300. doi: 10.1038/s41420-023-01580-1.
Since its discovery in 2019, coronavirus disease 2019 (COVID-2019) spans a wide clinical spectrum from the asymptomatic stage, mild infection, to severe pneumonia. In patients with COVID-2019, factors such as advanced age, diabetes, or hypertension are associated with a significantly increased risk of severe diseases and death. Of note, the mechanisms underlying differences in the risk and symptoms of COVID-2019 among different populations are still poorly characterized. Accordingly, it is imperative to elucidate potential pathophysiological mechanisms and develop targeted therapeutic approaches for COVID-2019 infection. N6-methyladenosine (mA) is one of the most common modifications in mammalian RNA transcripts and is widely found in messenger RNAs and some non-coding RNAs. It has been reported that mA methylation modifications are present in viral RNA transcripts, which are of great significance for the regulation of the viral life cycle. Furthermore, mA methylation has recently been found to be strongly associated with COVID-2019 infection. Therefore, this article reviews recent advances in studies related to the role of mA methylation in COVID-2019 infection.
自2019年被发现以来，2019冠状病毒病（COVID - 2019）涵盖了从无症状阶段、轻度感染到重症肺炎的广泛临床谱。在COVID - 2019患者中，高龄、糖尿病或高血压等因素与重症疾病和死亡风险显著增加相关。值得注意的是，不同人群中COVID - 2019风险和症状差异的潜在机制仍未得到充分描述。因此，阐明COVID - 2019感染的潜在病理生理机制并开发针对性治疗方法势在必行。N6 - 甲基腺嘌呤（m⁶A）是哺乳动物RNA转录本中最常见的修饰之一，广泛存在于信使RNA和一些非编码RNA中。据报道，m⁶A甲基化修饰存在于病毒RNA转录本中，对病毒生命周期的调控具有重要意义。此外，最近发现m⁶A甲基化与COVID - 2019感染密切相关。因此，本文综述了与m⁶A甲基化在COVID - 2019感染中的作用相关研究的最新进展。
