Shastri Malvika, Mallik Nabhajit, Kundu Reetu, Rohilla Manish, Gupta Parikshaa, Gupta Nalini, Srinivasan Radhika, Dey Pranab
Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Cytopathology. 2023 Jan;34(1):55-60. doi: 10.1111/cyt.13177. Epub 2022 Sep 22.
To describe the cytomorphological findings of all cerebrospinal fluid (CSF) cytology samples showing infiltration by chronic myeloid leukaemia (CML) and their correlation with haematological findings.
A retrospective analysis of all CSF samples reported as showing infiltration by CML on cytology from January 2014 to December 2021 was performed.
A total of 10 cases with positive CSF cytology were evaluated. The mean age of the patients was 34.1 years (range 17-70 years). There were more males than females. All cases were pre-diagnosed cases of CML on haematological investigations. On cytology, the smears showed atypical/immature blast-like cells, with a high nucleo-cytoplasmic ratio, opened-up chromatin, 1-2 conspicuous nucleoli and a scant to moderate amount of agranular to fine granular cytoplasm along with occasional granulocytic precursors. The shortest time interval for CSF positivity in a known case of CML was 5 months, and the longest interval was 11 years.
It is extremely uncommon to encounter CML infiltration in CSF. Timely analysis of CSF cytology samples can allow quick diagnosis and alter the patient management protocol.
描述所有显示慢性髓系白血病（CML）浸润的脑脊液（CSF）细胞学样本的细胞形态学表现及其与血液学检查结果的相关性。
对2014年1月至2021年12月期间细胞学报告显示CML浸润的所有脑脊液样本进行回顾性分析。
共评估了10例脑脊液细胞学阳性病例。患者的平均年龄为34.1岁（范围17 - 70岁）。男性多于女性。所有病例在血液学检查中均为CML预诊断病例。在细胞学检查中，涂片显示非典型/未成熟的原始样细胞，核质比高，染色质疏松，有1 - 2个明显的核仁，以及少量至中等量的无颗粒至细颗粒细胞质，偶尔可见粒细胞前体。已知CML病例中脑脊液阳性的最短时间间隔为5个月，最长间隔为11年。
脑脊液中出现CML浸润极为罕见。及时分析脑脊液细胞学样本可实现快速诊断并改变患者管理方案。
