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累及中枢神经系统的髓外慢性期慢性髓性白血病：一例报告。

Extramedullary chronic phase chronic myeloid leukaemia (CML) involving the central nervous system: A case report.

作者信息

Deshpande Akshay, Osman Dina, Murthy Vidhya, Hussein Hayder

机构信息

Department of Haematology University Hospitals Birmingham NHSFT Birmingham UK.

出版信息

EJHaem. 2024 Jun 25;5(4):859-862. doi: 10.1002/jha2.967. eCollection 2024 Aug.

DOI:10.1002/jha2.967
PMID:39157620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11327750/
Abstract

Chronic myeloid leukaemia (CML) has been classically described as a disease restricted to the bone marrow with very few reports of extramedullary involvement. CNS involvement with CML has been described in the literature as an aggressive disease in the leukaemic phase either preceding or coexisting with medullary blast crisis or seen in patients with long-term Imatinib therapy. No treatment consensus exists for this patient group and outcomes remain poor. We hereby present a very rare report of CNS involvement with chronic phase CML at diagnosis in a patient who presented with raised intracranial pressure and cranial nerve palsies.

摘要

慢性髓性白血病（CML）传统上被描述为一种局限于骨髓的疾病，关于髓外受累的报道极少。文献中已将CML的中枢神经系统受累描述为白血病期的侵袭性疾病，可先于或与髓系原始细胞危象同时存在，或见于接受长期伊马替尼治疗的患者。对于该患者群体，尚无治疗共识，预后仍然很差。我们在此报告一例非常罕见的病例，一名在诊断时处于慢性期CML的患者出现颅内压升高和颅神经麻痹，提示中枢神经系统受累。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0b/11327750/c0ddadaa78f6/JHA2-5-859-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0b/11327750/3d23d6785802/JHA2-5-859-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0b/11327750/c0ddadaa78f6/JHA2-5-859-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0b/11327750/3d23d6785802/JHA2-5-859-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0b/11327750/c0ddadaa78f6/JHA2-5-859-g002.jpg

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