Department of Bacteriology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Lett Appl Microbiol. 2022 Dec;75(6):1607-1616. doi: 10.1111/lam.13828. Epub 2022 Sep 14.
Atopic dermatitis (AD) is a chronic and relapsing multifactorial inflammatory skin disease that also affects dogs. The oral and gut microbiota are associated with many disorders, including allergy. Few studies have addressed the oral and gut microbiota in dogs, although the skin microbiota has been studied relatively well in these animals. Here, we studied the AD-associated oral and gut microbiota in 16 healthy and 9 AD dogs from a purebred Shiba Inu colony. We found that the diversity of the oral microbiota was significantly different among the dogs, whereas no significant difference was observed in the gut microbiota. Moreover, a differential abundance analysis detected the Family_XIII_AD3011_group (Anaerovoracaceae) in the gut microbiota of AD dogs; however, no bacterial taxa were detected in the oral microbiota. Third, the comparison of the microbial co-occurrence patterns between AD and healthy dogs identified differential networks in which the bacteria in the oral microbiota that were most strongly associated with AD were related to human periodontitis, whereas those in the gut microbiota were related to dysbiosis and gut inflammation. These results suggest that AD can alter the oral and gut microbiota in dogs.
特应性皮炎（AD）是一种慢性复发性多因素炎症性皮肤疾病，也会影响犬类。口腔和肠道微生物群与许多疾病有关，包括过敏。尽管已经对这些动物的皮肤微生物群进行了相对较好的研究，但很少有研究涉及犬类的口腔和肠道微生物群。在这里，我们研究了来自纯种柴犬群体的 16 只健康犬和 9 只 AD 犬的 AD 相关口腔和肠道微生物群。我们发现，犬类口腔微生物群的多样性存在显著差异，而肠道微生物群则没有显著差异。此外，差异丰度分析检测到 AD 犬肠道微生物群中的 Family_XIII_AD3011_group（Anaerovoracaceae）；然而，在口腔微生物群中未检测到任何细菌类群。第三，AD 犬和健康犬的微生物共生模式比较确定了差异网络，其中与 AD 相关性最强的口腔微生物群中的细菌与人类牙周炎有关，而肠道微生物群中的细菌则与肠道菌群失调和肠道炎症有关。这些结果表明，AD 可以改变犬类的口腔和肠道微生物群。
