Ylä-Herttuala S, Sumuvuori H, Karkola K, Möttönen M, Nikkari T
Atherosclerosis. 1987 May;65(1-2):109-15. doi: 10.1016/0021-9150(87)90012-8.
Men in Eastern Finland show a substantially higher rate of coronary heart disease (CHD) than men in the Western part of the country. To study possible differences in the biochemical composition and atherosclerotic involvement of coronary arteries between these two populations, we analyzed major lipid and non-lipid components of coronary arteries from 15- to 60-year-old Finnish men after accidental death. The material consisted of 59 age-matched pairs from East and West Finland, respectively, collected at successive autopsies during 1979-1983. The coronary arteries from East Finland contained significantly more esterified cholesterol and a higher percentage of oleate in cholesteryl esters. The findings were most conspicuous under the age of 40 years, and imply a higher degree of atherosclerosis together with an increased rate of intracellular cholesterol esterification in coronary arteries in Eastern as compared with Western Finland. The vessels from East Finland also tended to contain more free cholesterol and raised lesions, but the differences were not statistically significant. No major regional differences were seen in total phospholipids, phospholipid subfractions, DNA, calcium, collagen, total protein, or glycosaminoglycans.
芬兰东部男性的冠心病（CHD）发病率显著高于该国西部男性。为研究这两个人群冠状动脉的生化组成及动脉粥样硬化累及情况的可能差异，我们分析了15至60岁芬兰男性在意外死亡后冠状动脉的主要脂质和非脂质成分。材料分别由1979年至1983年连续尸检时收集的来自芬兰东部和西部的59对年龄匹配的样本组成。芬兰东部的冠状动脉含有显著更多的酯化胆固醇，且胆固醇酯中的油酸百分比更高。这些发现在40岁以下人群中最为明显，这意味着与芬兰西部相比，芬兰东部冠状动脉的动脉粥样硬化程度更高，同时细胞内胆固醇酯化率增加。芬兰东部的血管还往往含有更多的游离胆固醇和隆起病变，但差异无统计学意义。在总磷脂、磷脂亚组分、DNA、钙、胶原蛋白、总蛋白或糖胺聚糖方面未观察到主要的区域差异。
