无眼部受累的青少年系统性红斑狼疮患者的亚临床视网膜毛细血管异常
Subclinical Retinal Capillary Abnormalities in Juvenile Systemic Lupus Erythematosus without Ocular Involvement.
作者信息
Yılmaz Tuğan Büşra, Sönmez Hafize Emine, Yüksel Nurşen, Karabaş Levent
机构信息
Department of Ophthalmology, Kocaeli University, Kocaeli, Turkey.
Division of Pediatrics, Department of Pediatric Rheumatology, Kocaeli University, Kocaeli, Turkey.
出版信息
Ocul Immunol Inflamm. 2023 Apr;31(3):576-584. doi: 10.1080/09273948.2022.2116584. Epub 2022 Sep 6.
PURPOSE
This study aimed to evaluate subclinical retinal microvascular changes with OCTA in juvenile systemic lupus erythematosus (JSLE) patients without ocular involvement.
METHODS
Ten eyes of 10 JSLE and 13 eyes of 13 age and sex-matched healthy controls (HCs) were enrolled. The superficial (SCP) and deep capillary plexus (DCP), FAZ parameters, the flow area of the outer retina, and choriocapillaris were evaluated using OCTA.
RESULTS
All vessel density (VD) parameters in DCP were significantly lower in JSLE group compared to HCs. There was no significant difference between the groups in VD parameters of both SCP and ONH, FAZ, outer retina and choriocapillaris flow area. All DCP VD parameters showed a good ability to differentiate JSLE from HCs.
CONCLUSION
OCTA could detect retinal vascular impairment in the deep macular region in JSLE patients with normal ocular examination. Furthermore, all DCP VD parameters have a good ability to discriminate JSLE from HCs.
目的
本研究旨在利用光学相干断层扫描血管造影（OCTA）评估无眼部受累的青少年系统性红斑狼疮（JSLE）患者的亚临床视网膜微血管变化。
方法
纳入10例JSLE患者的10只眼以及13例年龄和性别匹配的健康对照者（HC）的13只眼。使用OCTA评估浅表毛细血管丛（SCP）和深层毛细血管丛（DCP）、黄斑无血管区（FAZ）参数、视网膜外层的血流面积以及脉络膜毛细血管。
结果
与HC相比，JSLE组DCP中的所有血管密度（VD）参数均显著降低。两组在SCP、视神经乳头（ONH）、FAZ、视网膜外层和脉络膜毛细血管血流面积的VD参数方面无显著差异。所有DCP VD参数均具有良好的区分JSLE与HC的能力。
结论
OCTA能够在眼部检查正常的JSLE患者中检测到黄斑深层区域的视网膜血管损伤。此外，所有DCP VD参数均具有良好的区分JSLE与HC 的能力。
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