通过光学相干断层扫描血管造影评估系统性红斑狼疮中的视网膜微血管变化。
Retinal microvascular changes in systemic lupus erythematosus assessed by optical coherence tomography angiography.
作者信息
Ferreira André, Viveiros Luísa, Faria Raquel, Bragança Francisca, Abreu Ana Carolina, Santos Daniela, Furtado Maria João, Lume Miguel, Menéres Pedro, Andrade José P
机构信息
Department of Ophthalmology, Unidade Local de Saúde de Santo António, Largo do Prof. Abel Salazar, Porto, 4099-001, Portugal.
Department of Biomedicine - Unit of Anatomy, Faculty of Medicine, University of Porto, Porto, Portugal.
出版信息
Int J Retina Vitreous. 2024 Dec 18;10(1):94. doi: 10.1186/s40942-024-00617-6.
PURPOSE
To assess the retinal microvasculature of Systemic Lupus Erythematosus (SLE) patients using Optical Coherence Tomography Angiography (OCTA).
METHODS
Twenty adult SLE patients without disease activity and no ocular manifestations were recruited and cross-sectionally assessed. A demographically similar cohort of healthy subjects was used for comparison. The main outcome is vascular density (VD). As secondary outcomes, foveal avascular zone (FAZ) parameters, total vessel length (TVL), vessel length density (VLD), vessel diameter and tortuosity, branchpoint density (BD) and fractal dimension (FD) were evaluated.
RESULTS
Forty eyes of 40 women (20 SLE patients and 20 healthy subjects) were enrolled with a mean ± SD age of 36.7 ± 9.9 years. In both the superficial and deep capillary plexuses, SLE patients presented significantly lower VD and TVL values, mean vessel diameter and FD (all p < 0.005). No significant differences were found in FAZ values. A negative correlation was found between age and FAZ parameters and between age and TVL, VLD and FD in the superficial capillary plexus (all p < 0.05).
CONCLUSIONS
This study supports the evidence of subclinical retinal microvascular changes in adult SLE patients, providing a more comprehensive characterization of vascular changes. We found vessel diameter and length and FD are decreased in SLE.
TRIAL REGISTRATION
NCT05863689, 2023-10-19.
目的
使用光学相干断层扫描血管造影（OCTA）评估系统性红斑狼疮（SLE）患者的视网膜微血管系统。
方法
招募20名无疾病活动且无眼部表现的成年SLE患者并进行横断面评估。使用人口统计学特征相似的健康受试者队列作为对照。主要观察指标是血管密度（VD）。作为次要观察指标，评估了黄斑无血管区（FAZ）参数、总血管长度（TVL）、血管长度密度（VLD）、血管直径和迂曲度、分支点密度（BD）和分形维数（FD）。
结果
纳入了40名女性的40只眼（20名SLE患者和20名健康受试者），平均年龄±标准差为36.7±9.9岁。在浅表和深部毛细血管丛中，SLE患者的VD、TVL值、平均血管直径和FD均显著降低（所有p<0.005）。FAZ值未发现显著差异。在浅表毛细血管丛中，年龄与FAZ参数之间以及年龄与TVL、VLD和FD之间存在负相关（所有p<0.05）。
结论
本研究支持成年SLE患者存在亚临床视网膜微血管变化的证据，对血管变化进行了更全面的特征描述。我们发现SLE患者的血管直径、长度和FD均降低。
试验注册
NCT05863689，2023年10月19日。
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