Reimche L D, Rooney M E, Hindmarsh K W, Gorecki D K, Remillard A J, Sankaran K
Am J Perinatol. 1987 Jul;4(3):262-5. doi: 10.1055/s-2007-999787.
Aminoglycoside antibiotics are frequently used for the treatment of suspected and confirmed sepsis in the newborn patient. In an attempt to evaluate gentamicin dosing based on serum creatinine concentrations, two groups of neonates were studied (infants less than 34 weeks n = 8 and greater than 34 weeks n = 14). The dosing interval was adjusted per protocol depending on the serum creatinine concentrations. Analysis of the results indicate reasonable therapeutic serum gentamicin trough and peak concentrations in most infants.
氨基糖苷类抗生素常用于治疗新生儿疑似和确诊的败血症。为了评估基于血清肌酐浓度的庆大霉素给药方案，对两组新生儿进行了研究（孕周小于34周的婴儿n = 8，孕周大于34周的婴儿n = 14）。给药间隔根据血清肌酐浓度按照方案进行调整。结果分析表明，大多数婴儿的血清庆大霉素谷浓度和峰浓度处于合理的治疗范围内。
