School of Nursing, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China.
Clinical Educational Department, Gansu Provincial Hospital, Lanzhou, Gansu, China, 730000.
J Diabetes Complications. 2022 Oct;36(10):108289. doi: 10.1016/j.jdiacomp.2022.108289. Epub 2022 Aug 31.
Further clarification is needed regarding the association between adverse childhood experiences (ACEs) and the risk of diabetes. To conduct a systematic review with meta-analysis of studies assessing the association between ACEs and the risk of diabetes.
We conducted a systematic literature search of PubMed, Embase, and Cochrane Library for published studies describing the association between ACEs and diabetes in December 2021. We examined the overall relationship between ACEs and diabetes and performed a subgroup analysis based on the type of ACEs, number of ACEs, and gender.
A total of 17 studies were included. The results of Meta-analysis showed the significant estimated effect of ACEs on diabetes (OR = 1.20, 95%CI: 1.07, 1.35). The subgroup analysis found a significant association between neglect (OR = 1.61, 95%CI: 1.11, 2.33), family dysfunction (OR = 1.14, 95%CI: 1.05, 1.24) and diabetes, respectively. Gender and the number of ACEs were factors that significantly affect the risk of diabetes.
The results suggest that ACEs were significantly associated with an elevated risk of diabetes, especially for exposure to neglect, family dysfunction, and two or more ACES. Effective ACEs screening for children and intervention among high-risk populations should be taken so as to reduce the incidence of diabetes.
需要进一步澄清不良童年经历（ACEs）与糖尿病风险之间的关联。为此，我们进行了一项系统评价和荟萃分析，以评估 ACEs 与糖尿病风险之间的关系。
我们于 2021 年 12 月在 PubMed、Embase 和 Cochrane Library 中进行了系统的文献检索，以查找描述 ACEs 与糖尿病之间关联的已发表研究。我们检查了 ACEs 与糖尿病之间的总体关系，并根据 ACEs 的类型、数量和性别进行了亚组分析。
共纳入 17 项研究。Meta 分析的结果表明，ACEs 对糖尿病有显著的估计影响（OR=1.20，95%CI：1.07，1.35）。亚组分析发现，忽视（OR=1.61，95%CI：1.11，2.33）、家庭功能障碍（OR=1.14，95%CI：1.05，1.24）与糖尿病之间存在显著关联。性别和 ACEs 的数量是显著影响糖尿病风险的因素。
结果表明，ACEs 与糖尿病风险显著相关，尤其是暴露于忽视、家庭功能障碍和两种或更多 ACEs 的情况下。应针对儿童进行有效的 ACEs 筛查，并对高危人群进行干预，以降低糖尿病的发病率。
