Wen Dan, Feng Li, Du Xin, Dong Jian-Zeng, Ma Chang-Sheng
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Int J Cardiol. 2023 Jan 15;371:413-417. doi: 10.1016/j.ijcard.2022.08.058. Epub 2022 Sep 5.
Takayasu arteritis (TA) is a rare large vasculitis with unknown etiology, which affects the aorta and its primary branches, as well as the pulmonary and coronary arteries. Cellular and humoral immunity, chronic inflammation, and genetic factors are involved into TA pathogenesis. Several biomarkers, such as MMPs, TIMPs, cytokines, cell adhesion molecules, autoantibodies, complements, PTX3, sRAGE, NT-proBNP, 8-isoPGF NO, acute-phase and immunology-related proteins, thrombogenicity markers, ghrelin leptin and adipokines, endothelial damage and repair factors, genetic markers etc., related to the pathogenesis could be observed in patients with TA. These biomarkers have revealed great values in early diagnosis, evaluating disease activity, guiding clinical treatment options, and thus demonstrated significant clinical application values in TA. The combination of biomarkers assay and imaging examination may detect TA more accurately. The aim of this review is to systemically observe the clinical significance of these biomarkers in TA.
大动脉炎（TA）是一种病因不明的罕见的大血管炎，累及主动脉及其主要分支，以及肺动脉和冠状动脉。细胞免疫和体液免疫、慢性炎症以及遗传因素参与了TA的发病机制。在TA患者中可以观察到几种与发病机制相关的生物标志物，如基质金属蛋白酶（MMPs）、金属蛋白酶组织抑制因子（TIMPs）、细胞因子、细胞黏附分子、自身抗体、补体、五聚素3（PTX3）、可溶性晚期糖基化终末产物受体（sRAGE）、N末端脑钠肽前体（NT-proBNP）、8-异前列腺素F2α（8-isoPGF2α）、急性期和免疫相关蛋白、血栓形成标志物、胃饥饿素、瘦素和脂肪因子、内皮损伤和修复因子、遗传标志物等。这些生物标志物在早期诊断、评估疾病活动度、指导临床治疗选择方面显示出巨大价值，因此在TA中具有显著的临床应用价值。生物标志物检测与影像学检查相结合可能更准确地检测出TA。本综述的目的是系统地观察这些生物标志物在TA中的临床意义。
