Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, Laboratório de Parasitologia, São Paulo, São Paulo, Brazil.
Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, São Paulo, Brazil.
Am J Trop Med Hyg. 2022 Sep 6;107(4):785-788. doi: 10.4269/ajtmh.22-0180. Print 2022 Oct 12.
The immunosuppressive effect of methotrexate has rarely been associated with reactivation of cutaneous leishmaniasis. Here we present a case of a cutaneous leishmaniasis patient with atypical clinical symptoms without splenomegaly but with cutaneous manifestations after treatment of rheumatoid arthritis with methotrexate and blood recovery of the parasite. Next-generation sequencing was used to identify Leishmania infantum chagasi in the patient's blood sample.
甲氨蝶呤的免疫抑制作用很少与皮肤利什曼病的复发有关。在这里，我们报告了一例皮肤利什曼病患者，其临床表现不典型，无脾肿大，但在接受甲氨蝶呤治疗类风湿关节炎和寄生虫血液恢复后出现皮肤表现。下一代测序用于鉴定患者血液样本中的婴儿利什曼原虫。
