State Key Laboratory of Molecular Oncology, Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, 325027, Zhejiang, PR China.
Commun Biol. 2022 Sep 6;5(1):917. doi: 10.1038/s42003-022-03806-x.
Pyroptosis, as a proinflammatory form of regulated cell death, plays an important role in multiple cancers. However, the diagnostic and prognostic values of pyroptosis and its interaction with tumor immunity in pan-cancer are still unclear. Here, we show an elevated general expression of 17 pyroptosis-associated genes of tumor patients with high-immune-activity and a reduced pyroptosis in low-immune-activity tumors. Moreover, pyroptosis is positively correlated with immune infiltration and immune-related signatures across 30 types of cancer. Furthermore, our experimental data suggest that pyroptosis directly modulate the expression of immune checkpoint molecules and cytokines. We generate a pyroptosis score model as a potential independent prognostic indicator in melanoma patients. Interestingly, 3 of pyroptosis-associated genes including CASP1, CASP4 and PYCARD, can predict the effectiveness of anti-PD-1 immunotherapy for patients with melanoma. Our study demonstrates that pyroptosis correlates with tumor immunity and prognosis, might be used as a potential target for immune therapy.
细胞焦亡作为一种炎性形式的细胞程序性死亡，在多种癌症中发挥着重要作用。然而，细胞焦亡及其与肿瘤免疫的相互作用在泛癌症中的诊断和预后价值仍不清楚。在这里，我们显示了肿瘤患者中 17 种与细胞焦亡相关基因的普遍高表达，以及低免疫活性肿瘤中细胞焦亡的减少。此外，细胞焦亡与 30 种癌症的免疫浸润和免疫相关特征呈正相关。此外，我们的实验数据表明，细胞焦亡直接调节免疫检查点分子和细胞因子的表达。我们生成了一个细胞焦亡评分模型，作为黑色素瘤患者潜在的独立预后指标。有趣的是，包括 CASP1、CASP4 和 PYCARD 在内的 3 种与细胞焦亡相关的基因可以预测黑色素瘤患者对抗 PD-1 免疫治疗的有效性。我们的研究表明，细胞焦亡与肿瘤免疫和预后相关，可能作为免疫治疗的潜在靶点。
