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药物基因组学指导心血管药物治疗。

Pharmacogenomics Informs Cardiovascular Pharmacotherapy.

机构信息

Touro College of Pharmacy, New York, NY, USA.

School of Medicine, New York Medical College, Valhalla, NY, USA.

出版信息

Methods Mol Biol. 2022;2547:201-240. doi: 10.1007/978-1-0716-2573-6_9.

Abstract

Precision medicine exemplifies the emergence of personalized treatment options which may benefit specific patient populations based upon their genetic makeup. Application of pharmacogenomics requires an understanding of how genetic variations impact pharmacokinetic and pharmacodynamic properties. This particular approach in pharmacotherapy is helpful because it can assist in and improve clinical decisions. Application of pharmacogenomics to cardiovascular pharmacotherapy provides for the ability of the medical provider to gain critical knowledge on a patient's response to various treatment options and risk of side effects.

摘要

精准医学体现了个性化治疗方案的出现,这些方案可以根据患者的基因构成使特定患者群体受益。药物基因组学的应用需要了解遗传变异如何影响药代动力学和药效学特性。这种药物治疗中的特殊方法是有帮助的,因为它可以协助并改善临床决策。药物基因组学在心血管药物治疗中的应用使医疗服务提供者能够获得关于患者对各种治疗选择的反应和副作用风险的关键知识。

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