Michael E. DeBakey Veterans Affairs Medical Center, and the Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Methods Mol Biol. 2022;2547:437-490. doi: 10.1007/978-1-0716-2573-6_16.
Drug addiction is a serious relapsing disease that has high costs to society and to the individual addicts. Treatment of these addictions is still in its nascency, with only a few examples of successful therapies. Therapeutic response depends upon genetic, biological, social, and environmental components. A role for genetic makeup in the response to treatment has been shown for several addiction pharmacotherapies with response to treatment based on individual genetic makeup. In this chapter, we will discuss the role of genetics in pharmacotherapies, specifically for cocaine, alcohol, and opioid dependences. The continued elucidation of the role of genetics should aid in the development of new treatments and increase the efficacy of existing treatments.
药物成瘾是一种严重的复发性疾病，给社会和个体成瘾者都带来了高昂的代价。这些成瘾的治疗仍处于起步阶段，只有少数成功治疗的例子。治疗反应取决于遗传、生物、社会和环境因素。遗传因素在几种成瘾药物治疗中的反应作用已经得到了证明，治疗反应基于个体的遗传构成。在这一章中，我们将讨论遗传学在药物治疗中的作用，特别是可卡因、酒精和阿片类药物依赖。遗传作用的不断阐明应该有助于开发新的治疗方法，并提高现有治疗方法的疗效。
