Nielsen David A, Nielsen Ellen M, Dasari Teja, Spellicy Catherine J
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA,
Methods Mol Biol. 2014;1175:589-624. doi: 10.1007/978-1-4939-0956-8_15.
Drug addiction is a serious relapsing disease that has high costs to society and to the individual addicts. Treatment of these addictions is still in its nascency, with only a few examples of successful therapies. Therapeutic response depends upon genetic, biological, social, and environmental components. A role for genetic makeup in the response to treatment has been shown for several addiction pharmacotherapies. For several addiction pharmacotherapies, response to treatment varies based on individual genetic makeup. In this chapter, we discuss the role of genetics in pharmacotherapies, specifically for cocaine, alcohol, and opioid dependences. The elucidation of the role of genetics should aid in the development of new treatments and increase the efficacy of existing treatments.
药物成瘾是一种严重的复发性疾病，对社会和个体成瘾者都造成高昂代价。这些成瘾问题的治疗仍处于起步阶段，仅有少数成功疗法的实例。治疗反应取决于遗传、生物、社会和环境因素。对于几种成瘾药物疗法，已经证明基因构成在治疗反应中发挥作用。对于几种成瘾药物疗法，治疗反应因个体基因构成而异。在本章中，我们将讨论遗传学在药物疗法中的作用，特别是针对可卡因、酒精和阿片类药物依赖的情况。阐明遗传学的作用应有助于开发新的治疗方法并提高现有治疗方法的疗效。
