Papuan Health and Community Development Foundation, Timika, Papua, Indonesia.
Department of Pediatrics, University of Gadjah Mada, Yogyakarta, Indonesia.
Malar J. 2022 Sep 6;21(1):255. doi: 10.1186/s12936-022-04268-6.
Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.
Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.
The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.
Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.
在人类实验性疟原虫感染中，具有免疫抑制功能的循环髓系来源的抑制细胞（MDSC）增加，但在临床疟疾中尚未进行研究。
使用流式细胞术，评估了来自印度尼西亚巴布亚未合并（n=8）和合并（n=4）及严重（n=16）疟原虫 vivax 疟疾患者以及严重（n=10）疟原虫 falciparum 疟疾患者冷冻保存样本中的循环多形核 MDSC。
与对照组相比，严重疟原虫 falciparum 疟疾患者的循环多形核 MDSC 绝对数量显著升高。无合并症 vivax 疟疾患者的多形核 MDSC 水平也升高到与严重疟原虫 falciparum 疟疾相当的水平。
控制免疫抑制 MDSC 的扩张可能对控制 falciparum 和 vivax 疟疾中有效的免疫反应的发展很重要。
