Zhang Allan, Wang Daniel, Diwan Sudhir, Lin Chih-Peng, Calodney Aaron, Rosenthal Richard, Chang Chien George C
Department of Radiology, University of Connecticut Health Center, Farmington, CT, USA.
Kansas City University, Kansas City, MO 64106, USA.
Regen Med. 2022 Nov;17(11):845-853. doi: 10.2217/rme-2021-0176. Epub 2022 Sep 6.
In regenerative medicine, cells, tissues and organs are often replaced, engineered or regrown in order to restore their function after they have been damaged or lost. Local anesthetics, corticosteroids and contrast agents are commonly employed for both diagnostic and therapeutic objectives in interventional pain and musculoskeletal treatments for regenerative medicine. There is growing evidence that routine injectables promote catabolism and disease processes. Thus, understanding the effects of these compounds on regenerative medicine injectates and target tissues such as tenocytes, chondrocytes, nucleus pulposus and ligamentous tissue is critical. This review includes the current research on the effects of local anesthetics and contrast agents, as well as their use and recommendations in regenerative medicine operations.
在再生医学中，细胞、组织和器官常常被替换、改造或再生，以便在其受损或丧失功能后恢复其功能。局部麻醉剂、皮质类固醇和造影剂通常用于再生医学的介入性疼痛和肌肉骨骼治疗中的诊断和治疗目的。越来越多的证据表明，常规注射剂会促进分解代谢和疾病进程。因此，了解这些化合物对再生医学注射剂和靶组织（如肌腱细胞、软骨细胞、髓核和韧带组织）的影响至关重要。本综述包括目前关于局部麻醉剂和造影剂的作用及其在再生医学手术中的应用和建议的研究。
