硝苯地平在正常志愿者中的药代动力学和药效学。
Pharmacokinetics and pharmacodynamics of nifedipine infusion in normal volunteers.
作者信息
Walley T J, Heagerty A M, Woods K L, Bing R F, Pohl J E, Barnett D B
出版信息
Br J Clin Pharmacol. 1987 Jun;23(6):693-701. doi: 10.1111/j.1365-2125.1987.tb03103.x.
Abstract
Two studies of the pharmacokinetics and pharmacodynamics of intravenous nifedipine infusion were performed: the first, a randomised double-blind crossover study of nifedipine and its vehicle in eight subjects, the second a dose ranging study in nine subjects. Nifedipine pharmacokinetics did not vary with dose or duration of infusion up to 8 h, and are similar to those reported for other nifedipine preparations. Nifedipine increased heart rate and forearm blood flow and decreased blood pressure after bolus injection but not during prolonged infusion. The vehicle decreased blood pressure and increased forearm blood flow after bolus injection but not during prolonged infusion. It did not affect heart rate. The vehicle's haemodynamic activity has not been previously recognised and is of potential importance in the study of this and similar preparations of calcium antagonists.
摘要
进行了两项关于静脉输注硝苯地平的药代动力学和药效学研究
第一项是在8名受试者中进行的硝苯地平及其溶媒的随机双盲交叉研究，第二项是在9名受试者中进行的剂量范围研究。硝苯地平的药代动力学在长达8小时的输注过程中不随剂量或输注持续时间而变化，并且与其他硝苯地平制剂报道的情况相似。静脉推注后硝苯地平可增加心率和前臂血流量并降低血压，但在长时间输注期间则不然。溶媒在静脉推注后可降低血压并增加前臂血流量，但在长时间输注期间则不然。它不影响心率。溶媒的血流动力学活性此前未被认识到，在研究此类及类似的钙拮抗剂制剂中具有潜在重要性。
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