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两例因滥用静脉注射硝苯地平导致的死亡病例。

Two deaths from intravenous nifedipine abuse.

作者信息

Purdue B N, Fernando G C, Busuttil A

机构信息

Department of Pathology, University Medical School, Edinburgh, Scotland.

出版信息

Int J Legal Med. 1991;104(5):289-91. doi: 10.1007/BF01369588.

DOI:10.1007/BF01369588
PMID:1782148
Abstract

An incident is reported in which 2 intravenous drug abusers died as the result of uncontrolled experimentation with intravenous injection of the common anti-hypertensive and anti-anginal drug Nifedipine (Adalat t.m. Bayer), probably in mistake for the commonly abused short-acting benzodiazepine drug Temazepam. Large quantities of Nifedipine were identified in the blood of both decreased men by gas chromatography. Apart from intense gastric mucosal congestion, pulmonary oedema and general visceral congestion, the autopsy findings were entirely nonspecific. The similarity in colour, shape and texture between capsules of Nifedipine and those of Temazepam is likely to have prompted the mistake.

摘要

据报道,有一起事件,两名静脉注射毒品者因误将常用的抗高血压和抗心绞痛药物硝苯地平(拜耳公司的心痛定商标)进行静脉注射试验且未加控制而死亡,他们可能误将其当作了常用的被滥用短效苯二氮䓬类药物替马西泮。通过气相色谱法在两名死者的血液中均检测出大量硝苯地平。除了胃黏膜严重充血、肺水肿和全身内脏充血外,尸检结果完全无特异性。硝苯地平胶囊与替马西泮胶囊在颜色、形状和质地方面的相似性很可能导致了这一错误。

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本文引用的文献

1
Clinical features and management of nifedipine overdosage in a patient with renal insufficiency.肾功能不全患者硝苯地平过量的临床特征与处理
J Toxicol Clin Toxicol. 1984;22(4):387-95. doi: 10.3109/15563658408992569.
2
Nifedipine overdose.硝苯地平过量
Am J Med. 1986 Aug;81(2):344-6. doi: 10.1016/0002-9343(86)90276-7.
3
Nifedipine infusion in acute myocardial infarction: experience in twelve patients.硝苯地平静脉输注治疗急性心肌梗死:12例患者的经验
Clin Cardiol. 1987 Dec;10(12):800-3. doi: 10.1002/clc.4960101205.
4
Pharmacokinetics and pharmacodynamics of nifedipine infusion in normal volunteers.硝苯地平在正常志愿者中的药代动力学和药效学。
Br J Clin Pharmacol. 1987 Jun;23(6):693-701. doi: 10.1111/j.1365-2125.1987.tb03103.x.
5
Nifedipine overdose.
Clin Cardiol. 1988 Jul;11(7):505-6. doi: 10.1002/clc.4960110714.
6
Determination of nifedipine and its three principal metabolites in plasma and urine by automated electron-capture capillary gas chromatography.采用自动电子捕获毛细管气相色谱法测定血浆和尿液中的硝苯地平及其三种主要代谢物。
J Chromatogr. 1988 Mar 4;425(1):107-19. doi: 10.1016/0378-4347(88)80011-2.
7
Psychoactive substance use and related behaviours of 135 regular illicit drug users in Scotland.苏格兰135名经常使用非法药物者的精神活性物质使用情况及相关行为
Drug Alcohol Depend. 1989 Apr;23(2):95-101. doi: 10.1016/0376-8716(89)90013-6.
8
Buprenorphine and temazepam abuse by drug takers in Glasgow--an increase.格拉斯哥吸毒者对丁丙诺啡和替马西泮的滥用情况——呈上升趋势。
Br J Addict. 1989 Apr;84(4):439-41. doi: 10.1111/j.1360-0443.1989.tb00589.x.
9
Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.硝苯地平。对其在缺血性心脏病、高血压及相关心血管疾病中的药效学、药代动力学特性及治疗效果的综述。
Drugs. 1985 Sep;30(3):182-274. doi: 10.2165/00003495-198530030-00002.
10
Buprenorphine and temazepam--abuse.丁丙诺啡和替马西泮——滥用情况
Br J Addict. 1990 Feb;85(2):301-3. doi: 10.1111/j.1360-0443.1990.tb03088.x.