年龄、性别和体重对氨苯砜乙酰化表型的影响。
Influence of age, sex and body weight on the dapsone acetylation phenotype.
作者信息
Philip P A, Gayed S L, Rogers H J, Crome P
出版信息
Br J Clin Pharmacol. 1987 Jun;23(6):709-13. doi: 10.1111/j.1365-2125.1987.tb03105.x.
Abstract
The acetylation of dapsone (DDS) was determined by estimation of the ratio of monoacetyldapsone (MADDS) to DDS concentrations in plasma following a single dose of DDS in 337 white British subjects (193 female; 144 male). The percentage of slow DDS acetylators in the whole group was 60.3%. There was no statistically significant difference in this proportion between 191 elderly subjects (age greater than 65 years) and 143 young subjects (age less than 30 years). Although there was a small (66.3%) but significant (P = 0.033) preponderance of slow acetylators in the young male group there was no difference in the distribution of acetylator phenotypes between the sexes among either the elderly group or in the whole population studied. No correlation was found between absolute body weight and MADDS/DDS ratios.
摘要
在337名英国白人受试者（193名女性；144名男性）中，单次服用氨苯砜（DDS）后，通过估算血浆中一乙酰氨苯砜（MADDS）与DDS的浓度比来测定DDS的乙酰化情况。整个组中慢乙酰化型DDS者的比例为60.3%。191名老年受试者（年龄大于65岁）和143名年轻受试者（年龄小于30岁）之间的这一比例无统计学显著差异。虽然年轻男性组中慢乙酰化型者的比例略高（66.3%）且具有显著性（P = 0.033），但在老年组或整个研究人群中，两性之间乙酰化型表型的分布并无差异。未发现绝对体重与MADDS/DDS比值之间存在相关性。
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