选择性 C(sp)-H 键功能化：铁-乙酰丙酮卤化物在环境条件下的催化氯化和溴化。
Selective functionalization of C(sp)-H bonds: catalytic chlorination and bromination by Iron-acacen-halide under ambient condition.
机构信息
Department of Science and Environmental Studies, The Education University of Hong Kong, 10 Lo Ping Road, Tai Po, Hong Kong SAR, China.
Department of Chemistry, The City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, SAR, China.
出版信息
Chem Commun (Camb). 2022 Sep 22;58(76):10627-10630. doi: 10.1039/d2cc02924c.
The oxidative catalytic halogenations of the C(sp)-H bond of alkanes promoted by Fe(acacen)Cl (1III-Cl) and Fe(acacen)Br (1III-Br) in the presence of trifluoroacetic acid (TFA) were investigated. Four major steps were involved: (i) formation of [Fe(acacen)(oxo)X] species (X = Cl or Br), (ii) hydrogen-atom transfer, (iii) halogen atom rebound, and (iv) regeneration of 1III-Cl or 1III-Br. TFA played a significant role in (i) forming the high-valent iron-oxo intermediate and (ii) generating the reaction selectivity.
在三氟乙酸 (TFA) 的存在下，通过 Fe(acacen)Cl (1III-Cl) 和 Fe(acacen)Br (1III-Br) 促进的烷烃的 C(sp)-H 键的氧化催化卤化反应得到了研究。该反应涉及四个主要步骤：(i) [Fe(acacen)(oxo)X] 物种（X = Cl 或 Br）的形成，(ii) 氢原子转移，(iii) 卤素原子的回弹，和 (iv) 1III-Cl 或 1III-Br 的再生。TFA 在 (i) 形成高价铁氧中间体和 (ii) 产生反应选择性方面发挥了重要作用。
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