• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.

作者信息

Sievers Philipp, Sill Martin, Schrimpf Daniel, Friedel Dennis, Sturm Dominik, Gardberg Maria, Kurian Kathreena M, Krskova Lenka, Vicha Ales, Schaller Tina, Hagel Christian, Abdullaev Zied, Aldape Kenneth, Jacques Thomas S, Korshunov Andrey, Wick Wolfgang, Pfister Stefan M, von Deimling Andreas, Jones David T W, Sahm Felix

机构信息

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

出版信息

Acta Neuropathol. 2022 Nov;144(5):1049-1052. doi: 10.1007/s00401-022-02492-7. Epub 2022 Sep 7.

DOI:10.1007/s00401-022-02492-7
PMID:36070143
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9547789/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a564/9547789/c9b02051c918/401_2022_2492_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a564/9547789/c9b02051c918/401_2022_2492_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a564/9547789/c9b02051c918/401_2022_2492_Fig1_HTML.jpg

相似文献

1
Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.表观遗传学分析揭示了一类小儿型神经胶质神经元肿瘤的子集，其特征是涉及多种可靶向激酶的致癌基因融合。
Acta Neuropathol. 2022 Nov;144(5):1049-1052. doi: 10.1007/s00401-022-02492-7. Epub 2022 Sep 7.
2
PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.PATZ1 融合定义了一种具有广泛组织学谱的新型分子上独特的神经上皮肿瘤实体。
Acta Neuropathol. 2021 Nov;142(5):841-857. doi: 10.1007/s00401-021-02354-8. Epub 2021 Aug 21.
3
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.伴 ATRX 改变、激酶融合及间变特征的胶质神经元肿瘤（GTAKA）：一种具有复发性 NTRK 基因融合的分子上独特的脑肿瘤类型。
Acta Neuropathol. 2023 May;145(5):667-680. doi: 10.1007/s00401-023-02558-0. Epub 2023 Mar 18.
4
Low-grade glioneuronal tumors with FGFR2 fusion resolve into a single epigenetic group corresponding to 'Polymorphous low-grade neuroepithelial tumor of the young'.具有FGFR2融合的低级别神经胶质神经元肿瘤可归为一个单一的表观遗传组，对应于“青少年多形性低级别神经上皮肿瘤”。
Acta Neuropathol. 2021 Sep;142(3):595-599. doi: 10.1007/s00401-021-02352-w. Epub 2021 Jul 28.
5
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.全面分析伴有 FGFR1 改变的多种低级别神经上皮肿瘤，揭示出具有神经胶-神经元肿瘤特征的独特分子特征。
Acta Neuropathol Commun. 2020 Aug 28;8(1):151. doi: 10.1186/s40478-020-01027-z.
6
Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.乳头状胶质神经元肿瘤 (PGNT) 表现出特征性的甲基化谱和涉及 PRKCA 的融合。
Acta Neuropathol. 2019 May;137(5):837-846. doi: 10.1007/s00401-019-01969-2. Epub 2019 Feb 13.
7
A novel LARGE1-AFF2 fusion expanding the molecular alterations associated with the methylation class of neuroepithelial tumors with PATZ1 fusions.一种新型的 LARGE1-AFF2 融合，扩展了与甲基化类神经上皮肿瘤相关的分子改变，这些肿瘤与 PATZ1 融合有关。
Acta Neuropathol Commun. 2022 Feb 3;10(1):15. doi: 10.1186/s40478-022-01317-8.
8
EWSR1-PATZ1 gene fusion may define a new glioneuronal tumor entity.EWSR1-PATZ1 基因融合可能定义了一种新的胶质神经元肿瘤实体。
Brain Pathol. 2019 Jan;29(1):53-62. doi: 10.1111/bpa.12619. Epub 2018 Jul 13.
9
Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion.乳头状胶质神经元肿瘤：SLC44A1-PRKCA 融合的组织学和分子特征及诊断价值。
Acta Neuropathol Commun. 2015 Dec 15;3:85. doi: 10.1186/s40478-015-0264-5.
10
Spinal cord astroblastoma with an EWSR1-BEND2 fusion classified as a high-grade neuroepithelial tumour with MN1 alteration.伴有EWSR1-BEND2融合的脊髓成纤维细胞瘤被归类为伴有MN1改变的高级别神经上皮肿瘤。
Neuropathol Appl Neurobiol. 2020 Feb;46(2):190-193. doi: 10.1111/nan.12593. Epub 2020 Jan 8.

引用本文的文献

1
Pineal region high-grade neuroepithelial tumors with NTRK fusions map to the novel methylation class "diffuse high-grade glioma, IDH-wild type, subtype E".具有NTRK融合的松果体区高级别神经上皮肿瘤属于新的甲基化类别“弥漫性高级别胶质瘤，IDH野生型，E亚型”。
Acta Neuropathol. 2025 Sep 9;150(1):26. doi: 10.1007/s00401-025-02934-y.
2
cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics.cIMPACT-NOW更新9：关于全基因组DNA甲基化谱在中枢神经系统肿瘤诊断中的应用建议。
Neurooncol Adv. 2025 Jan 3;7(1):vdae228. doi: 10.1093/noajnl/vdae228. eCollection 2025 Jan-Dec.
3

本文引用的文献

1
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.2021 年世卫组织中枢神经系统肿瘤分类：概述。
Neuro Oncol. 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106.
2
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.全面分析伴有 FGFR1 改变的多种低级别神经上皮肿瘤，揭示出具有神经胶-神经元肿瘤特征的独特分子特征。
Acta Neuropathol Commun. 2020 Aug 28;8(1):151. doi: 10.1186/s40478-020-01027-z.
3
Pediatric low-grade glioma in the era of molecular diagnostics.
Rare Oncogenic Fusions in Pediatric Central Nervous System Tumors: A Case Series and Literature Review.
儿童中枢神经系统肿瘤中的罕见致癌融合：病例系列及文献综述
Cancers (Basel). 2024 Sep 30;16(19):3344. doi: 10.3390/cancers16193344.
4
Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion.具有 CLIP2::MET 融合的两例儿科胶质神经元肿瘤的临床、病理和基因组特征。
Acta Neuropathol Commun. 2024 Apr 22;12(1):63. doi: 10.1186/s40478-024-01776-1.
5
Rare variant of large pediatric glioneuronal tumor with novel MYO5A::NTRK3 fusion: illustrative case.具有新型MYO5A::NTRK3融合的小儿大型神经胶质神经元肿瘤罕见变异型：病例说明
J Neurosurg Case Lessons. 2024 Mar 4;7(10). doi: 10.3171/CASE23638.
6
Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular.两例具有 NTRK2 融合的新型肿瘤，位于室管膜下瘤的甲基化亚型中，包括一例脑室内部的肿瘤。
Brain Pathol. 2024 May;34(3):e13223. doi: 10.1111/bpa.13223. Epub 2023 Nov 23.
7
A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant-type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma.全面分析婴儿中枢神经系统肿瘤，以提高婴儿型大脑半球胶质瘤与促结缔组织增生性婴儿型节细胞胶质瘤/星形细胞瘤的鉴别标准。
Brain Pathol. 2023 Sep;33(5):e13182. doi: 10.1111/bpa.13182. Epub 2023 Jun 22.
8
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.伴 ATRX 改变、激酶融合及间变特征的胶质神经元肿瘤（GTAKA）：一种具有复发性 NTRK 基因融合的分子上独特的脑肿瘤类型。
Acta Neuropathol. 2023 May;145(5):667-680. doi: 10.1007/s00401-023-02558-0. Epub 2023 Mar 18.
9
Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.多组学生物标志物神经病理学提高儿科神经肿瘤学的诊断准确性。
Nat Med. 2023 Apr;29(4):917-926. doi: 10.1038/s41591-023-02255-1. Epub 2023 Mar 16.
儿童低级别胶质瘤的分子诊断时代。
Acta Neuropathol Commun. 2020 Mar 12;8(1):30. doi: 10.1186/s40478-020-00902-z.
4
Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.广泛结节性成神经管细胞瘤（MBEN）的转录组分析揭示了两个具有潜在临床意义的肿瘤亚群，VSNL1 作为强有力的预后标志物。
Acta Neuropathol. 2020 Mar;139(3):583-596. doi: 10.1007/s00401-019-02102-z. Epub 2019 Nov 28.
5
Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.在神经病理学诊断中，对福尔马林固定石蜡包埋标本进行常规 RNA 测序可鉴定出具有诊断和治疗意义的基因融合。
Acta Neuropathol. 2019 Nov;138(5):827-835. doi: 10.1007/s00401-019-02039-3. Epub 2019 Jul 5.
6
Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA.乳头状胶质神经元肿瘤 (PGNT) 表现出特征性的甲基化谱和涉及 PRKCA 的融合。
Acta Neuropathol. 2019 May;137(5):837-846. doi: 10.1007/s00401-019-01969-2. Epub 2019 Feb 13.
7
Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile.透明隔和侧脑室黏液样神经胶质神经元肿瘤由复发性血小板衍生生长因子受体A（PDGFRA）p.K385突变和类似弥漫性星形细胞瘤伴少突胶质细胞成分（DNT）的甲基化谱所定义。
Acta Neuropathol. 2018 Aug;136(2):339-343. doi: 10.1007/s00401-018-1883-2. Epub 2018 Jul 13.
8
FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.FGFR1:TACC1 融合是分子定义的室管膜下神经细胞瘤中的常见事件。
Acta Neuropathol. 2018 Aug;136(2):293-302. doi: 10.1007/s00401-018-1882-3. Epub 2018 Jul 5.
9
Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.神经胶质神经元肿瘤中靶向BCAN-NTRK1融合后的临床和影像学反应
NPJ Precis Oncol. 2017 Mar 20;1(1):5. doi: 10.1038/s41698-017-0009-y. eCollection 2017.
10
Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.分子定义的弥漫性软脑膜神经胶质神经元肿瘤（DLGNT）包括两个具有不同临床和遗传特征的亚组。
Acta Neuropathol. 2018 Aug;136(2):239-253. doi: 10.1007/s00401-018-1865-4. Epub 2018 May 15.