Braak S, Su T, Krudop W, Pijnenburg Y A L, Reus L M, van der Wee N, Bilderbeck A C, Dawson G R, van Rossum I Winter-, Campos A Vieira, Arango C, Saris I M J, Kas M J, Penninx B W J H
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, the Netherlands.
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.
Eur Neuropsychopharmacol. 2022 Nov;64:19-29. doi: 10.1016/j.euroneuro.2022.08.005. Epub 2022 Sep 5.
Social dysfunction is commonly present in neuropsychiatric disorders of schizophrenia (SZ) and Alzheimer's disease (AD). Theory of Mind (ToM) deficits have been linked to social dysfunction in disease-specific studies. Nevertheless, it remains unclear how ToM is related to social functioning across these disorders, and which factors contribute to this relationship. We investigated transdiagnostic associations between ToM and social functioning among SZ/AD patients and healthy controls, and explored to what extent these associations relate to information processing speed or facial emotion recognition capacity. A total of 163 participants were included (SZ: n=56, AD: n=50 and age-matched controls: n=57). Social functioning was assessed with the Social Functioning Scale (SFS) and the De Jong-Gierveld Loneliness Scale (LON). ToM was measured with the Hinting Task. Information processing speed was measured by the Digit Symbol Substitution Test (DSST) and facial emotion recognition capacity by the facial emotion recognition task (FERT). Case-control deficits in Hinting Task performance were larger in AD (r = -0.57) compared to SZ (r = -0.35). Poorer Hinting Task performance was transdiagnostically associated with the SFS (β = 1.20, p<0.01) and LON (β = -0.27, p<0.05). DSST, but not FERT, reduced the association between the SFS and Hinting Task performance, however the association remained significant (β = 0.95, p<0.05). DSST and FERT performances did not change the association between LON and Hinting Task performance. Taken together, ToM deficits are transdiagnostically associated with social dysfunction and this is partly related to reduced information processing speed.
社会功能障碍在精神分裂症（SZ）和阿尔茨海默病（AD）等神经精神疾病中普遍存在。在针对特定疾病的研究中，心理理论（ToM）缺陷与社会功能障碍有关。然而，目前尚不清楚ToM在这些疾病中如何与社会功能相关，以及哪些因素促成了这种关系。我们研究了SZ/AD患者和健康对照者中ToM与社会功能之间的跨诊断关联，并探讨了这些关联在多大程度上与信息处理速度或面部情绪识别能力有关。总共纳入了163名参与者（SZ组：n = 56，AD组：n = 50，年龄匹配的对照组：n = 57）。使用社会功能量表（SFS）和德容 - 吉尔维尔德孤独量表（LON）评估社会功能。使用暗示任务测量ToM。通过数字符号替换测试（DSST）测量信息处理速度，通过面部情绪识别任务（FERT）测量面部情绪识别能力。与SZ组（r = -0.35）相比，AD组在暗示任务表现中的病例对照缺陷更大（r = -0.57）。较差的暗示任务表现与SFS（β = 1.20，p<0.01）和LON（β = -0.27，p<0.05）存在跨诊断关联。DSST而非FERT降低了SFS与暗示任务表现之间的关联，然而该关联仍然显著（β = 0.95，p<0.05）。DSST和FERT表现并未改变LON与暗示任务表现之间的关联。综上所述，ToM缺陷与社会功能障碍存在跨诊断关联，且这部分与信息处理速度降低有关。
