走钢丝：神经元如何在神经退行性变的交叉线上保持稳定。
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration.
机构信息
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
出版信息
Cell Metab. 2022 Sep 6;34(9):1227-1229. doi: 10.1016/j.cmet.2022.08.013.
In this issue of Cell Metabolism, Traxler et al. report a metabolic switch in neurons that hinges on the critical balance of pyruvate kinase M (PKM) isoform ratios. Using directly induced neurons (iNs) derived from patients with Alzheimer's disease (AD), the work delineates the impact of an AD-specific switch from PKM1 to PKM2 onto neuronal resilience against neurodegeneration.
本期《细胞代谢》中，Traxler 等人报道了神经元代谢的转换，其关键在于丙酮酸激酶 M（PKM）同工型比例的关键平衡。该工作使用源自阿尔茨海默病（AD）患者的直接诱导神经元（iNs），阐明了 AD 特异性从 PKM1 向 PKM2 的转换对神经元抵抗神经退行性变的影响。
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