Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC H3A 1A3, Canada.
Cell Metab. 2022 Sep 6;34(9):1231-1233. doi: 10.1016/j.cmet.2022.08.011.
In this issue of Cell Metabolism, Xue et al. propose that the mitochondrial calcium uniporter (MCU) binds uncoupling protein 1 (UCP1) via the MCU regulator (EMRE) to form a protein complex that the authors term the "thermoporter." Through gain- and loss-of-function experiments, the authors infer that the thermoporter promotes calcium influx into the mitochondrial matrix to enhance NADH production, which supports thermogenesis in brown adipose tissue (BAT).
在本期《细胞代谢》中，薛等人提出线粒体钙单向转运蛋白（MCU）通过 MCU 调节蛋白（EMRE）与解偶联蛋白 1（UCP1）结合形成一个蛋白复合物，作者将其称为“热载体”。通过功能获得和功能丧失实验，作者推断热载体促进钙离子内流入线粒体基质以增强 NADH 的产生，从而支持棕色脂肪组织（BAT）的产热。
