Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Lancet. 2022 Oct 1;400(10358):1157-1170. doi: 10.1016/S0140-6736(22)01439-8. Epub 2022 Sep 4.
Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by cardiac failure or fluid overload. ARDS is defined by the Berlin criteria. In this Series paper the diagnosis, management, outcomes, and long-term sequelae of ARDS are reviewed. Potential limitations of the ARDS definition and evidence that could inform future revisions are considered. Guideline recommendations, evidence, and uncertainties in relation to ARDS management are discussed. The future of ARDS strives towards a precision medicine approach, and the framework of treatable traits in ARDS diagnosis and management is explored.
急性呼吸窘迫综合征（ARDS）的特征是急性低氧性呼吸衰竭，伴有胸部影像学上的双侧浸润，但不能完全用心力衰竭或液体超负荷来解释。ARDS 的定义是柏林标准。在本系列论文中，回顾了 ARDS 的诊断、治疗、结局和长期后遗症。考虑了 ARDS 定义的潜在局限性和可能为未来修订提供信息的证据。讨论了 ARDS 管理方面的指南建议、证据和不确定性。ARDS 的未来努力朝着精准医学的方法发展，并探讨了 ARDS 诊断和管理中可治疗特征的框架。
