State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
Fitoterapia. 2022 Oct;162:105293. doi: 10.1016/j.fitote.2022.105293. Epub 2022 Sep 5.
Six new compounds, including three lignans (1a, 1b, and 2), two abietane-type diterpenoids (3 and 4), and a triterpenoid (5), together with 13 known compounds (6a, 6b, and 7-17) were isolated from the aerial parts of Gaultheria leucocarpa var. yunnanensis. Their structures were elucidated by analysis of spectroscopic data involving NMR, IR, UV, and HRESIMS. The absolute configurations of lignans were confirmed by experimental and calculated ECD spectra. The anti-inflammatory and antioxidant activities of the isolates were evaluated. Compounds 12, 13, and 15 showed inhibitory effects against the LPS-induced production of NO in BV-2 microglial cells with the IC values of 30.50, 23.26, and 13.02 μM, respectively. In addition, compounds 2 and 7 performed moderate DPPH radical scavenging activities.
从滇白珠（Gaultheria leucocarpa var. yunnanensis）的地上部分分离得到 6 个新化合物，包括 3 个木脂素（1a、1b 和 2）、2 个松香烷型二萜（3 和 4）和 1 个三萜（5），以及 13 个已知化合物（6a、6b 和 7-17）。通过 NMR、IR、UV 和 HRESIMS 等光谱数据分析阐明了它们的结构。通过实验和计算的 ECD 光谱确定了木脂素的绝对构型。评估了分离物的抗炎和抗氧化活性。化合物 12、13 和 15 对 LPS 诱导的 BV-2 小胶质细胞中 NO 产生具有抑制作用，IC 值分别为 30.50、23.26 和 13.02 μM。此外，化合物 2 和 7 表现出中等的 DPPH 自由基清除活性。
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