云南白珠树中三个新的酚苷和一个新的木脂素苷。
Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis.
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
出版信息
Fitoterapia. 2024 Jan;172:105740. doi: 10.1016/j.fitote.2023.105740. Epub 2023 Nov 7.
Three new phenolic glycosides (1-3) and a new lignan glycoside (4), together with five known compounds (5-9) were isolated from the ethanol extract of the aerial part of Gaultheria leucocarpa var. yunnanensis (Franch.) T.Z.Hsu & R.C.Fang. Their structures were determined on the basis of spectroscopic techniques, experimental and calculated ECD spectra, acid hydrolysis, and enzymatic hydrolysis experiments. All the isolates were evaluated for their anti-inflammatory and antioxidant activities. Compounds 7 and 8 exhibited inhibitory effects against the LPS-induced production of NO with IC of 63.71 and 10.66 μM, respectively, compared to L-NMMA having an IC of 6.95 μM. Besides, compound 7 also represented significant DPPH radical scavenging activity with EC of 18.75 μM, comparable with vitamin C (EC = 15.77 μM).
从云南白珠树（Gaultheria leucocarpa var. yunnanensis（Franch.）T.Z.Hsu & R.C.Fang）地上部分的乙醇提取物中分离得到三个新的酚糖苷（1-3）和一个新的木脂素糖苷（4），以及五个已知化合物（5-9）。基于光谱技术、实验和计算ECD 光谱、酸水解和酶水解实验，确定了它们的结构。所有分离物均评估了其抗炎和抗氧化活性。与 L-NMMA 的 IC 为 6.95 μM 相比，化合物 7 和 8 分别对 LPS 诱导的 NO 产生具有 63.71 和 10.66 μM 的抑制作用。此外，化合物 7 还表现出显著的 DPPH 自由基清除活性，EC 为 18.75 μM，与维生素 C（EC = 15.77 μM）相当。
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