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来自……的具有抗氧化和抗菌活性的次生代谢产物

Secondary Metabolites with Antioxidant and Antimicrobial Activities from .

作者信息

Tang Jiandong, Li Ruonan, Wu Boxiao, Tang Junrong, Kan Huan, Zhao Ping, Zhang Yingjun, Wang Weihua, Liu Yun

机构信息

Key Laboratory of Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of Education, Southwest Forestry University, Kunming 650224, China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650224, China.

出版信息

Curr Issues Mol Biol. 2024 Jul 2;46(7):6769-6782. doi: 10.3390/cimb46070404.

Abstract

has important ornamental, medicinal, and food value. It also has tremendous potential for exploiting bioactivities. However, the bioactivities of secondary metabolites in have not been reported. The structures of compounds were determined by spectral analysis and nuclear magnetic resonance (NMR) combined with the available literature on secondary metabolites of leaves. In this study, 15 compounds were identified, including 5 flavonoids (-), a galactosylglycerol derivative (), a terpenoid (), 4 lignans (-), and 4 phenolic acids (-). Compounds - and - were isolated from the genus for the first time. The remaining compounds were also isolated from for the first time. Evaluation of antioxidant and antimicrobial activities revealed that compounds and - exhibited stronger antioxidant activity than the positive drug ascorbic acid, while compounds , , and showed similar activity to ascorbic acid. The minimum inhibitory concentration (MIC) of antibacterial activity for compounds , , , , and against was comparable to that of the positive control drug tetracycline at a concentration of 62.50 µg/mL; other secondary metabolites inhibited and at concentrations ranging from 125-250 µg/mL.

摘要

具有重要的观赏、药用和食用价值。它在开发生物活性方面也具有巨大潜力。然而,[具体植物名称]中次生代谢产物的生物活性尚未见报道。通过光谱分析和核磁共振(NMR)结合关于[具体植物名称]叶次生代谢产物的现有文献确定了化合物的结构。在本研究中,鉴定出15种化合物,包括5种黄酮类化合物(-)、1种半乳糖基甘油衍生物()、1种萜类化合物()、4种木脂素(-)和4种酚酸(-)。化合物-和-首次从[具体植物属名]中分离得到。其余化合物也首次从[具体植物名称]中分离得到。抗氧化和抗菌活性评估表明,化合物和-表现出比阳性药物抗坏血酸更强的抗氧化活性,而化合物、和表现出与抗坏血酸相似的活性。化合物、、、和对[具体细菌名称]的抗菌活性最低抑菌浓度(MIC)与浓度为62.50μg/mL的阳性对照药物四环素相当;其他次生代谢产物在125 - 250μg/mL的浓度范围内抑制[具体细菌名称]和[另一种具体细菌名称]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a59/11275493/8d31406cc130/cimb-46-00404-g001.jpg

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