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TAFRO 综合征以急性腹痛和肾上腺肿胀为首发表现

Acute Abdomen and Adrenal Swelling as the First Manifestations of TAFRO Syndrome.

机构信息

Department of Hematology, Sapporo Kiyota Hospital, Japan.

Department of Internal Medicine, Sapporo Kiyota Hospital, Japan.

出版信息

Intern Med. 2023 Jun 1;62(11):1675-1681. doi: 10.2169/internalmedicine.0267-22. Epub 2022 Sep 6.

DOI:10.2169/internalmedicine.0267-22
PMID:36070944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10292987/
Abstract

TAFRO syndrome, a rare systemic inflammatory disorder, commonly develops in an acute or subacute manner, with an aggressive clinical behavior. A substantial number of cases of TAFRO syndrome presenting with abdominal pain, and adrenal abnormalities on imaging have also been reported. A 54-year-old man developed severe acute abdominal pain. Bilateral adrenal swelling was detected on computed tomography. Although the abdominal pain resolved spontaneously, a fever and anasarca were observed. The patient was eventually diagnosed with TAFRO syndrome, and corticosteroid administration resulted in remission. TAFRO syndrome should be included in the differential diagnosis of acute abdomen and adrenal abnormalities.

摘要

TAFRO 综合征是一种罕见的系统性炎症性疾病,通常以急性或亚急性方式发病,具有侵袭性的临床行为。大量 TAFRO 综合征病例表现为腹痛和影像学上的肾上腺异常。一位 54 岁男性出现严重的急性腹痛。计算机断层扫描发现双侧肾上腺肿胀。尽管腹痛自行缓解,但出现发热和水肿。最终该患者被诊断为 TAFRO 综合征,给予皮质类固醇治疗后缓解。TAFRO 综合征应纳入急性腹痛和肾上腺异常的鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/6996e03b1d3f/1349-7235-62-1675-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/5f34c9dfc529/1349-7235-62-1675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/bc883cb70776/1349-7235-62-1675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/6cc73939af9e/1349-7235-62-1675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/6996e03b1d3f/1349-7235-62-1675-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/5f34c9dfc529/1349-7235-62-1675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/bc883cb70776/1349-7235-62-1675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/6cc73939af9e/1349-7235-62-1675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62fb/10292987/6996e03b1d3f/1349-7235-62-1675-g004.jpg

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本文引用的文献

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Bilateral Adrenal Infarctions as an Initial Manifestation of TAFRO Syndrome: A Case Report and Review of the Literature.双侧肾上腺梗死作为TAFRO综合征的初始表现:一例病例报告及文献复习
Intern Med. 2022 Mar 1;61(5):743-747. doi: 10.2169/internalmedicine.7976-21. Epub 2021 Aug 13.
2
Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease.特发性多中心 Castleman 病伴血小板减少、浮肿、发热、网状纤维纤维化、肾功能不全和器官肿大(TAFRO)临床亚型的验证性国际定义。
Am J Hematol. 2021 Oct 1;96(10):1241-1252. doi: 10.1002/ajh.26292. Epub 2021 Jul 28.
3
Fatal case of TAFRO syndrome with unilateral adrenal hemorrhage in early-stage disease.
TAFRO 综合征伴单侧肾上腺出血的早期致死性病例。
J Clin Exp Hematop. 2021;61(2):109-113. doi: 10.3960/jslrt.20065.
4
Complete Resolution of a Case of TAFRO Syndrome Accompanied by Mediastinal Panniculitis, Adrenal Lesion, and Liver Damage with Hyperbilirubinemia.TAFRO 综合征伴纵隔脂膜炎、肾上腺病变和肝损伤伴高胆红素血症病例完全缓解。
Intern Med. 2021 Apr 15;60(8):1303-1309. doi: 10.2169/internalmedicine.5850-20. Epub 2020 Nov 16.
5
Recovery from prolonged thrombocytopenia in patients with TAFRO syndrome: case series and literature review.TAFRO 综合征患者血小板减少持续时间延长后的恢复:病例系列及文献复习。
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