Giles D E, Schlesser M A, Rush A J, Orsulak P J, Fulton C L, Roffwarg H P
Biol Psychiatry. 1987 Jul;22(7):872-82. doi: 10.1016/0006-3223(87)90085-0.
To evaluate the replicability of our previous findings of increased incidence of biological dysregulation in endogenous depression, we have studied a new series of patients with major depressive disorder, unipolar type (n = 103). The subtypes compared were defined by Research Diagnostic Criteria and were endogenous/nonendogenous, primary/secondary, and Winokur's family history classification. As an extension of the research, we evaluated the endogenous subtype more precisely by distinguishing those patients who met criteria for probable endogenous, comparing them to both endogenous and nonendogenous depressed patients. The findings of the replication study were consistent with our earlier report; the incidence of both dexamethasone nonsuppression and reduced rapid eye movement (REM) latency was higher in those with endogenous depression. Findings for each of the other subtypes revealed no differences. The probable endogenous depressed patients were comparable to the nonendogenous depressed patients in all variables measured.
为评估我们之前关于内源性抑郁症生物调节异常发生率增加这一发现的可重复性，我们研究了一组新的单相重度抑郁症患者（n = 103）。所比较的亚型由研究诊断标准定义，包括内源性/非内源性、原发性/继发性以及维诺克家族史分类。作为该研究的拓展，我们通过区分符合可能内源性标准的患者，并将其与内源性和非内源性抑郁症患者进行比较，更精确地评估了内源性亚型。重复研究的结果与我们早期的报告一致；内源性抑郁症患者中地塞米松不抑制和快速眼动（REM）潜伏期缩短的发生率更高。其他每种亚型的研究结果均未显示出差异。在所有测量变量中，可能内源性抑郁症患者与非内源性抑郁症患者相当。
