Hubain P P, Souery D, Jönck L, Staner L, Van Veeren C, Kerkhofs M, Mendlewicz J, Linkowski P
Department of Psychiatry, Erasme Hospital, University of Brussels, Belgium.
Eur Neuropsychopharmacol. 1995 Jun;5(2):129-34. doi: 10.1016/0924-977X(95)00011-D.
In order to investigate the reliability of the endogenous concept of depressive illness with some sleep EEG parameters, we studied 39 male inpatients suffering from a nonbipolar major depressive episode (15 endogenous (MDDE) and 24 nonendogenous (MDDNE)) and 20 age and sex matched normal controls (C). All patients were diagnosed according to the Research Diagnostic Criteria (RDC) and the endogenous character of the episode was assessed with the Newcastle Endogenous Depression Diagnostic Index. We found significant differences for the following variables between the three groups (MDDE, MDDNE and C): sleep period time (SPT), REM latency, stage II, slow wave sleep (SWS), REM latency expressed as a continuous variable and REM latency expressed as a dichotomizing variable with a threshold of 50 min. These variables were used to compare the endogenous and the nonendogenous depressed patients and also the major depressed patients and the normal controls. Significant differences were observed between all depressed patients and control subjects for amount of SWS and REM latency which were both reduced in endogenous and nonendogenous depressed patients. No significant difference was observed between endogenous and nonendogenous depressed patients, except for the REM latency expressed with a threshold of 50 min (more frequently observed in endogenous depressed patients). Our data support the observation that SWS and REM latency are decreased in major depressive patients. However, in this age and sex controlled study, subtyping nonbipolar major depressive disorder for an endogenous character by the Newcastle Endogenous Depression Diagnostic Index (NEDDI) did not reveal further significant differences for sleep EEG variables, except for the shortening of the REM latency expressed as a dichotomizing variable.
为了用一些睡眠脑电图参数研究抑郁症内源性概念的可靠性，我们研究了39名患有非双相性重度抑郁发作的男性住院患者（15名内源性患者（MDDE）和24名非内源性患者（MDDNE））以及20名年龄和性别匹配的正常对照者（C）。所有患者均根据研究诊断标准（RDC）进行诊断，并用纽卡斯尔内源性抑郁诊断指数评估发作的内源性特征。我们发现三组（MDDE、MDDNE和C）在以下变量上存在显著差异：睡眠时间（SPT）、快速眼动潜伏期、第二阶段、慢波睡眠（SWS）、以连续变量表示的快速眼动潜伏期以及以50分钟为阈值的二分变量表示的快速眼动潜伏期。这些变量用于比较内源性和非内源性抑郁症患者以及重度抑郁症患者和正常对照者。在所有抑郁症患者和对照受试者之间，观察到慢波睡眠量和快速眼动潜伏期存在显著差异，内源性和非内源性抑郁症患者的这两个指标均降低。除了以50分钟为阈值表示的快速眼动潜伏期（在内源性抑郁症患者中更常见）外，内源性和非内源性抑郁症患者之间未观察到显著差异。我们的数据支持重度抑郁症患者慢波睡眠和快速眼动潜伏期降低的观察结果。然而，在这项年龄和性别匹配的研究中，通过纽卡斯尔内源性抑郁诊断指数（NEDDI）对非双相性重度抑郁症进行内源性特征亚型分类，除了以二分变量表示的快速眼动潜伏期缩短外，未发现睡眠脑电图变量有进一步的显著差异。
