基础游离皮质醇/18-羟基-11-脱氧皮质酮（18-OH-DOC）比值在内源性抑郁症中的诊断效能：与地塞米松抑制试验的比较

Diagnostic performance of basal free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) ratio in endogenous depression: comparison with the dexamethasone suppression test.

作者信息

Demey-Ponsart E, Ansseau M, Sulon J, von Frenckell R, Cerfontaine J L, Papart P, Franck G, Geenen V, Legros J J

出版信息

Biol Psychiatry. 1987 Aug;22(8):947-56. doi: 10.1016/0006-3223(87)90004-7.

Abstract

We assessed the 8:00 AM ratio of free cortisol/18-hydroxy-11-deoxycorticosterone (18-OH-DOC) in 56 endogenous depressive inpatients and in 22 normal volunteers. A ratio higher than 40 was associated with a diagnostic sensitivity for endogenous depression of 75%, a specificity of 95.5%, and a diagnostic confidence of 97.7%. These diagnostic results were at least equivalent to the Dexamethasone Suppression Test (DST) using a cortisol cut-off limit of 5 micrograms/dl. This may thus represent a simpler procedure than the DST in the diagnostic analysis of endogenous depression.

摘要

我们评估了56名内源性抑郁住院患者和22名正常志愿者上午8点的游离皮质醇/18-羟基-11-脱氧皮质酮（18-OH-DOC）比值。比值高于40与内源性抑郁的诊断敏感性为75%、特异性为95.5%以及诊断可信度为97.7%相关。这些诊断结果至少等同于使用皮质醇临界值5微克/分升的地塞米松抑制试验（DST）。因此，在对内源性抑郁的诊断分析中，这可能代表了一种比DST更简单的方法。