正常仰卧男性18-羟基-11-脱氧皮质酮的24小时变化曲线：与皮质醇和醛固酮的关系

24 hour profile of 18-hydroxy-11-deoxycorticosterone in normal supine man: relationship with cortisol and aldosterone.

作者信息

Sulon J, Sparano F, Sciarra F, Giaquinto G, Genard P

出版信息

Clin Endocrinol (Oxf). 1978 May;8(5):367-72. doi: 10.1111/j.1365-2265.1978.tb02170.x.

DOI:10.1111/j.1365-2265.1978.tb02170.x

Abstract

Daily profiles of plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) were studied in four normal supine men on a normal sodium intake. Blood was taken every hour from 01.00 to 24.00 hours. Plasma cortisol (F) and aldosterone (A) were determined hourly for comparative studies. 18-OH-DOC fluctuated considerably during the 24 h period of investigation, the highest values being found during the early morning hours in synchrony with F. The episodic secretions of 18-OH-DOC were also significantly correlated with those of A, which in turn paralleled those of F. We conclude that ACTH, plays a definite role in the regulation of 18-OH-DOC in normal supine men on a normal sodium diet.

摘要

在四名正常钠摄入量的仰卧男性中研究了血浆18-羟-11-脱氧皮质酮（18-OH-DOC）的每日变化情况。从凌晨1点到24点每小时采集一次血液。每小时测定血浆皮质醇（F）和醛固酮（A）以进行对比研究。在24小时的研究期间，18-OH-DOC波动很大，最高值出现在清晨，与F同步。18-OH-DOC的间歇性分泌也与A的分泌显著相关，而A又与F平行。我们得出结论，促肾上腺皮质激素（ACTH）在正常钠饮食的仰卧男性中对18-OH-DOC的调节中起明确作用。