金黄色葡萄球菌感染糖尿病溃疡的优化小鼠模型。
An optimized mouse model of Staphylococcus aureus infected diabetic ulcers.
机构信息
School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, Portugal.
出版信息
BMC Res Notes. 2022 Sep 7;15(1):293. doi: 10.1186/s13104-022-06170-5.
OBJECTIVE
Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobial resistance. Novel therapies targeting DFI are therefore a pressing research need for which proper models of disease are required.
RESULTS
Here, we present an optimized diabetic mouse model of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, that resemble key features of DFI, such as pathogen invasion through wound bed and surrounding tissue, necrosis, persistent inflammation and impaired wound healing. Thus, in a time-efficient manner and using simple techniques, this model represents a suitable approach for studying emerging therapies targeting DFI caused by MRSA.
目的
糖尿病足感染（DFI）是一个主要的医疗保健负担，由于糖尿病内在的病理生理改变以及抗菌药物耐药性的惊人增加，治疗具有挑战性。因此，针对 DFI 的新型治疗方法是迫切需要研究的，这需要有适当的疾病模型。
结果
在这里，我们提出了一种优化的耐甲氧西林金黄色葡萄球菌（MRSA）感染伤口的糖尿病小鼠模型，该模型类似于 DFI 的关键特征，如病原体通过伤口床和周围组织的入侵、坏死、持续炎症和受损的伤口愈合。因此，这种模型以高效的方式并使用简单的技术，代表了研究针对由 MRSA 引起的 DFI 的新兴治疗方法的合适方法。
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