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须癣毛癣菌会延迟ob/ob小鼠的伤口愈合。

Trichophyton mentagrophytes delays wound healing in ob/ob mice.

作者信息

Aruga Kohsuke, Takehara Kimie, Kametaka Satoshi

机构信息

Biofunctional Sciences, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

Fundamental Nursing, Department of Health Sciences, Fujita Health University Graduate School of Health Science, Toyoake, Aichi, Japan.

出版信息

Int Wound J. 2024 Dec;21(12):e70118. doi: 10.1111/iwj.70118.

DOI:10.1111/iwj.70118
PMID:39675779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11646656/
Abstract

A wide variety of microbial species, including Trichophyton spp., have been detected in diabetic foot ulcers (DFUs). In particular, Trichophyton spp. cause tinea pedis (i.e., athlete's foot) and onychomycosis. However, investigations regarding the correlation between Trichophyton spp. and delayed wound healing are limited to case reports. Moreover, histological changes in wounds caused by Trichophyton spp. remain unclear. In this study, we sought to confirm the delayed wound healing phenotype caused by Trichophyton mentagrophytes infection in a full-thickness excisional wound ob/ob mouse model through histopathological analysis. The inoculation of skin wounds in ob/ob mice with T. mentagrophytes sporules resulted in significant delay on wound healing. Further histopathological analyses demonstrated that the delayed wound healing in ob/ob mice was accompanied by reduced collagen fibre formation and inhibited granulation tissue formation, with spores and elongated mycelia retained in the wound bed and along the wound edges. This suggests that T. mentagrophytes colonization of wounds potentially contributes to delayed wound healing in patients with diabetes. These results suggest that neglected tinea pedis is a potential risk factor for delayed wound healing and progression to refractory wounds in patients with DFU.

摘要

在糖尿病足溃疡（DFU）中已检测到多种微生物，包括毛癣菌属。特别是，毛癣菌属会引起足癣（即运动员脚癣）和甲癣。然而，关于毛癣菌属与伤口愈合延迟之间相关性的研究仅限于病例报告。此外，由毛癣菌属引起的伤口组织学变化仍不清楚。在本研究中，我们试图通过组织病理学分析，在全层切除伤口的ob/ob小鼠模型中确认须癣毛癣菌感染导致的伤口愈合延迟表型。用须癣毛癣菌孢子接种ob/ob小鼠的皮肤伤口会导致伤口愈合显著延迟。进一步的组织病理学分析表明，ob/ob小鼠伤口愈合延迟伴随着胶原纤维形成减少和肉芽组织形成受抑制，伤口床和伤口边缘保留有孢子和细长的菌丝体。这表明伤口中须癣毛癣菌的定植可能导致糖尿病患者伤口愈合延迟。这些结果表明，被忽视的足癣是DFU患者伤口愈合延迟和发展为难治性伤口的潜在危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/945e247a8d48/IWJ-21-e70118-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/a7c6ffe2b314/IWJ-21-e70118-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/ed0873647413/IWJ-21-e70118-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/07572c7a0ad4/IWJ-21-e70118-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/044934e4ea0c/IWJ-21-e70118-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/a13a1de07606/IWJ-21-e70118-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/bcb96b50014b/IWJ-21-e70118-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/945e247a8d48/IWJ-21-e70118-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/a7c6ffe2b314/IWJ-21-e70118-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/ed0873647413/IWJ-21-e70118-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/07572c7a0ad4/IWJ-21-e70118-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/044934e4ea0c/IWJ-21-e70118-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/a13a1de07606/IWJ-21-e70118-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/bcb96b50014b/IWJ-21-e70118-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77b/11646656/945e247a8d48/IWJ-21-e70118-g002.jpg

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本文引用的文献

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Impact of foot ulcer-related factors on quality of life in patients with diabetes: Prospective observational study.足部溃疡相关因素对糖尿病患者生活质量的影响：前瞻性观察研究。
Int Wound J. 2024 May;21(5):e14895. doi: 10.1111/iwj.14895.
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The wound microbiota: microbial mechanisms of impaired wound healing and infection.伤口菌群：影响伤口愈合和感染的微生物机制。
Nat Rev Microbiol. 2024 Aug;22(8):507-521. doi: 10.1038/s41579-024-01035-z. Epub 2024 Apr 4.
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Elastin and collagen fibres in cutaneous wound healing.皮肤伤口愈合中的弹性纤维和胶原纤维。
Exp Dermatol. 2024 Mar;33(3):e15052. doi: 10.1111/exd.15052.
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Quality of Life in Patients with Diabetic Foot Ulcers: A Cross-sectional Study.糖尿病足溃疡患者的生活质量：一项横断面研究。
Adv Skin Wound Care. 2022 Dec 1;35(12):661-668. doi: 10.1097/01.ASW.0000891864.37619.34.
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IL-17 and IL-22 are pivotal cytokines to delay wound healing of infected skin.IL-17 和 IL-22 是延迟感染皮肤伤口愈合的关键细胞因子。
Front Immunol. 2022 Oct 7;13:984016. doi: 10.3389/fimmu.2022.984016. eCollection 2022.
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The use of mice in diabetes research: The impact of physiological characteristics, choice of model and husbandry practices.糖尿病研究中使用小鼠：生理特征、模型选择和饲养实践的影响。
Diabet Med. 2021 Dec;38(12):e14711. doi: 10.1111/dme.14711. Epub 2021 Oct 16.
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis.小鼠切除性伤口愈合模型及组织形态计量学伤口分析
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