Shen Yifeng, You Yaodong, Zhu Kun, Fang Chunyan, Yu Xujun, Chang Degui
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2022 Aug 22;13:969257. doi: 10.3389/fphar.2022.969257. eCollection 2022.
Extensive research on the blood-testis barrier has been undertaken in recent years. However, no systematic bibliometric study has been conducted on this subject. Our research aimed to identify the hotspots and frontiers of blood-testis barrier research and to serve as a guide for future scientific research and decision-making in the field. Studies on the blood-testis barrier were found in the Web of Science Core Collection. VOSviewer, CiteSpace, and Microsoft Excel were used to conduct the bibliometric and visual analyses. We found 942 blood-testis barrier studies published in English between 1992 and 2022. The number of annual publications and citations increased significantly between 2011 and 2022, notably in the United States. China and the United States, the US Population Council, Endocrinology, and Cheng C. Yan were the most productive countries, institution, journal, and author, respectively. The study keywords indicated that blood-testis barrier research involves a variety of compositional features (tight junctions, cytoskeleton, adherens junctions), cell types (Sertoli cells, germ cells, Leydig cells, stem cells), reproductive toxicity (cadmium, nanoparticles, bisphenol-a), and relevant mechanisms (spermatogenesis, apoptosis, oxidative stress, dynamics, inflammation, immune privilege). The composition and molecular processes of the blood-testis barrier as well as the blood-testis barrier in male infertility patients are the primary research hotspots in this field. In addition, future research will likely focus on treatment and the development of novel medications that target signal pathways in oxidative stress and apoptosis to preserve the blood-testis barrier. Further studies must extend to clinical diagnosis and therapy.
近年来，人们对血睾屏障进行了广泛的研究。然而，尚未对该主题进行系统的文献计量学研究。我们的研究旨在确定血睾屏障研究的热点和前沿，并为该领域未来的科学研究和决策提供指导。在科学网核心合集中检索了关于血睾屏障的研究。使用VOSviewer、CiteSpace和Microsoft Excel进行文献计量和可视化分析。我们发现1992年至2022年间共发表了942篇关于血睾屏障的英文研究。2011年至2022年间，年发表量和被引次数显著增加，尤其是在美国。中国和美国、美国人口理事会、《内分泌学》以及程C. 严分别是发文量最多的国家、机构、期刊和作者。研究关键词表明，血睾屏障研究涉及多种组成特征（紧密连接、细胞骨架、黏附连接）、细胞类型（支持细胞、生殖细胞、间质细胞、干细胞）、生殖毒性（镉、纳米颗粒、双酚A）以及相关机制（精子发生、细胞凋亡、氧化应激、动态变化、炎症、免疫豁免）。血睾屏障的组成和分子过程以及男性不育患者的血睾屏障是该领域的主要研究热点。此外，未来的研究可能会集中在针对氧化应激和细胞凋亡信号通路以保护血睾屏障的治疗方法和新型药物的开发上。进一步的研究必须扩展到临床诊断和治疗。
