Li Yangshuo, Wang Kaili, Ding Jie, Sun Shuai, Ni Zhexin, Yu Chaoqin
Department of Traditional Chinese Gynecology, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.
Front Pharmacol. 2022 Aug 22;13:954684. doi: 10.3389/fphar.2022.954684. eCollection 2022.
The gut microbiota (GM) has received extensive attention in recent years, and its key role in the establishment and maintenance of health and in the development of diseases has been confirmed. A strong correlation between the GM and the progression of endometriosis (EMS) has been observed in emerging research. Alterations in the composition and function of the GM have been described in many studies on EMS. In contrast, the GM in the environment of EMS, especially the GM metabolites, such as bile acids and short-chain fatty acids that are related to the pathogenesis of EMS, can promote disease progression. Chenodeoxycholic acid (CDCA), as one of the primary bile acids produced in the liver, is metabolized by various enzymes derived from the GM and is critically important in maintaining intestinal homeostasis and regulating lipid and carbohydrate metabolism and innate immunity. Given that the complexity of CDCA as a signalling molecule and the interaction between the GM and EMS have not been clarified, the role of the CDCA and GM in EMS should be understood from a novel perspective. However, few articles on the relationship between CDCA and EMS have been reviewed. Therefore, we review the available and possible potential links between CDCA, the GM and EMS and put forward the hypothesis that CDCA and its derivative obeticholic acid can improve the symptoms of EMS through the GM.
近年来，肠道微生物群（GM）受到了广泛关注，其在健康的建立与维持以及疾病发展中的关键作用已得到证实。在新兴研究中，已观察到GM与子宫内膜异位症（EMS）进展之间存在密切关联。许多关于EMS的研究都描述了GM的组成和功能变化。相反，EMS环境中的GM，尤其是与EMS发病机制相关的GM代谢产物，如胆汁酸和短链脂肪酸，可促进疾病进展。鹅去氧胆酸（CDCA）作为肝脏产生的主要胆汁酸之一，由GM衍生的各种酶进行代谢，在维持肠道稳态、调节脂质和碳水化合物代谢以及先天免疫方面至关重要。鉴于CDCA作为信号分子的复杂性以及GM与EMS之间的相互作用尚未阐明，应从新的角度理解CDCA和GM在EMS中的作用。然而，关于CDCA与EMS关系的文章很少被综述。因此，我们综述了CDCA、GM与EMS之间现有的以及可能的潜在联系，并提出假说，即CDCA及其衍生物奥贝胆酸可通过GM改善EMS症状。
