Sun Yuanfeng, Yang Sophine Xin, Xie Min, Zou Ke, Tang Xiangdong
Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Business Administration of Business School, Sichuan University, Chengdu, China.
Front Neurol. 2022 Aug 22;13:985321. doi: 10.3389/fneur.2022.985321. eCollection 2022.
This study was aimed to investigate the characteristics of the amplitude of low-frequency fluctuation (ALFF) at specific frequencies in severe obstructive sleep apnea (OSA) patients. A comparison was made between pre-CPAP treatment and one night after continuous positive airway pressure (CPAP) treatment.
30 severe OSA patients and 19 healthy controls (HC) were recruited. The ALFF method was used to assess the local features of spontaneous brain activity and calculated at different bands (slow-5 and slow-4). A correlation analysis was performed to evaluate the relationship between the changes of the ALFF and polysomnography data.
Compared with HC, in slow-5 frequency band, OSA patients showed significantly decreased ALFF in the left inferior temporal gyrus, and significantly increased ALFF in the left middle frontal gyrus, left inferior frontal gyrus, triangular part, right superior frontal gyrus, dorsolateral and right middle temporal gyrus. In slow-4 frequency, there was significantly decreased ALFF in the right inferior temporal gyrus, and significantly increased ALFF in the left precuneus, right posterior cingulate gyrus and right median cingulate besides the slow-5 difference band showed. Compared with pre-CPAP, we found that after CPAP treatment, ALFF signals in the left insula in slow-5 and left caudate in slow-4 increased, but the calcarine in slow-4 significantly reduced. Correlation analysis showed that the left angular slow-4 band change was positively correlated with the slow wave sleep change ( = 0.4933, = 0.0056). The left cerebellum 6 slow-5 band change was positively correlated with the duration of the REM sleep change ( = 0.4563, = 0.0113), and the left cerebellum 6 slow-4 band change was also positively correlated with the mean blood oxygen change in the REM ( = 0.4591, = 0.0107) and NREM sleep ( = 0.4492, = 0.0128).
We found that the use of slow-4 was more specific in OSA studies. These results suggested that the severe OSA patients have frequency-related abnormal spontaneous neural activity, which may contribute to a better understanding of the pathological basis of OSA-related diseases and provide a potential therapeutic target for OSA patients.
本研究旨在调查重度阻塞性睡眠呼吸暂停（OSA）患者特定频率下的低频振幅（ALFF）特征。对持续气道正压通气（CPAP）治疗前和治疗后一晚进行比较。
招募30例重度OSA患者和19例健康对照（HC）。采用ALFF方法评估自发脑活动的局部特征，并在不同频段（慢波5和慢波4）进行计算。进行相关性分析以评估ALFF变化与多导睡眠图数据之间的关系。
与HC相比，在慢波5频段，OSA患者左侧颞下回的ALFF显著降低，而左侧额中回、左侧额下回三角部、右侧额上回背外侧部及右侧颞中回的ALFF显著升高。在慢波4频段，除慢波5差异频段显示的变化外，右侧颞下回的ALFF显著降低，左侧楔前叶、右侧后扣带回及右侧中央扣带回的ALFF显著升高。与CPAP治疗前相比，我们发现CPAP治疗后，慢波5频段左侧岛叶和慢波4频段左侧尾状核的ALFF信号增加，但慢波4频段的距状裂显著降低。相关性分析显示，左侧角回慢波4频段变化与慢波睡眠变化呈正相关（r = 0.4933，P = 0.0056）。左侧小脑6慢波5频段变化与快速眼动睡眠持续时间变化呈正相关（r = 0.4563，P = 0.0113），左侧小脑6慢波4频段变化也与快速眼动睡眠（r = 0.4591，P = 0.0107）和非快速眼动睡眠（r = 0.4492，P = 0.0128）中的平均血氧变化呈正相关。
我们发现慢波4在OSA研究中更具特异性。这些结果表明，重度OSA患者存在与频率相关的异常自发神经活动，这可能有助于更好地理解OSA相关疾病的病理基础，并为OSA患者提供潜在的治疗靶点。
