Zhao Xin, Zhang Chenxu, Zeng Ping, Zhou Jin, Li Xiaoying, Zhang Xiaoqing
Department of Health Management, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China.
Department of Occupational Health, Sleep Medicine Center and ENT, West China School of Public Health and West China Forth Hospital, Sichuan University, No.18, Section 3, Renmin South Road, Wuhou District, Chengdu, 610041, Sichuan Province, China.
Sleep Breath. 2025 Jul 12;29(4):240. doi: 10.1007/s11325-025-03406-z.
Few articles focus on the effect of CPAP on the nocturnal blood pressure in OSA patients. This study aims to evaluate the effects of continuous positive airway pressure (CPAP) therapy on nocturnal blood pressure in individuals with obstructive sleep apnea-hypopnea syndrome (OSAHS), which fills the research gap. Additionally, differences in nocturnal blood pressure measurements before and after CPAP therapy were analyzed across varying disease severities.
A total of 80 individuals with newly diagnosed OSAHS who sought care at the Sleep Respiratory Disease Diagnosis and Treatment Center at West China Fourth Hospital of Sichuan University between December 2022 and June 2023 were included in this study. All participants completed a single night of CPAP therapy, administered from 10:00 PM on day 1 to 6:00 AM on day 2, during which nocturnal blood pressure measurements were assessed using pulse transit time.
Following CPAP therapy, significant reductions were observed in the mean nocturnal diastolic blood pressure (nDBP) [(78.40 ± 13.06) vs. (74.03 ± 9.90) mmHg] and the nocturnal blood pressure fluctuation index (NBPFI) [(21.38 ± 19.95) vs. (5.81 ± 5.40) n/h] (p < 0.05). However, no significant difference was noted in the mean nocturnal systolic blood pressure (p > 0.05). Subgroup analysis based on disease severity: The reductions in nDBP [(6.16 ± 11.89) vs. (-0.32 ± 12.43) mmHg, p < 0.05] and nocturnal blood pressure fluctuation [(20.48 ± 19.05) vs. (2.59 ± 4.44) n/h, p < 0.05] were significantly greater in the severe group compared to the mild-to-moderate group.
The findings suggested that CPAP therapy could potentially contribute to reductions in nDBP and the NBPFI in individuals with OSAHS, with more noticeable effects in patients with severe OSAHS.
很少有文章关注持续气道正压通气（CPAP）对阻塞性睡眠呼吸暂停（OSA）患者夜间血压的影响。本研究旨在评估持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者夜间血压的影响，填补了这一研究空白。此外，还分析了不同疾病严重程度的患者在CPAP治疗前后夜间血压测量值的差异。
本研究纳入了2022年12月至2023年6月期间在四川大学华西第四医院睡眠呼吸疾病诊断与治疗中心就诊的80例新诊断的OSAHS患者。所有参与者均接受了一晚的CPAP治疗，从第1天晚上10:00至第2天早上6:00，在此期间使用脉搏传输时间评估夜间血压。
CPAP治疗后，夜间平均舒张压（nDBP）[（78.40±13.06）mmHg对（74.03±9.90）mmHg]和夜间血压波动指数（NBPFI）[（21.38±19.95）n/h对（5.81±5.40）n/h]显著降低（p<0.05）。然而，夜间平均收缩压无显著差异（p>0.05）。基于疾病严重程度的亚组分析：与轻度至中度组相比，重度组的nDBP降低幅度更大[（6.16±11.89）mmHg对（-0.32±12.43）mmHg，p<0.05]，夜间血压波动也更大[（20.48±19.05）n/h对（2.59±4.44）n/h，p<0.05]。
研究结果表明，CPAP治疗可能有助于降低OSAHS患者的nDBP和NBPFI，对重度OSAHS患者的效果更明显。
