Yang Haotian, Tan Ziqi, Zhang Yizhen, Sun Jiaqi, Huang Peng
Queen Mary School, Nanchang University, Nanchang, Jiangxi 330036, P.R. China.
Center for Evidence-Based Medicine, School of Public Health, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Oncol Lett. 2022 Aug 12;24(4):340. doi: 10.3892/ol.2022.13460. eCollection 2022 Oct.
Patients with certain ABO classifications are at increased risk of certain types of malignancies. In the present study, a meta-analysis was performed to explore the association between the ABO blood group and the risk of lung cancer from an evidence-based medical perspective. The PubMed, Embase, Web of Science, Medline, China National Knowledge Infrastructure, Google Scholar, Science Direct and Wanfang databases were searched for relevant papers. Review Manger 5.4 was used to analyze the association between the ABO blood group and the risk of lung cancer. Trial Sequential Analysis (TSA) was used to determine whether the sample size of the meta-analysis was sufficient. A total of 29 studies were included in this paper. The results of the case-controlled studies showed that the proportion of patients with blood type A in patients with lung cancer was significantly higher than that in healthy individuals [odds ratio (OR), 1.10; 95% confidence interval (CI), 1.02-1.19]. Based on the subgroup analysis, type A blood showed heterogeneity in ethnicity and source of control (social or hospital). Additionally, type O blood was determined to be a protective factor for lung cancer in Caucasians (OR, 0.92; 95% CI, 0.85-0.99). TSA results suggested that there were sufficient participants in the case-controlled studies. Overall, the results of the cohort studies showed that the risk of lung cancer and blood type were weakly associated, and that the difference was not statistically significant. The case-controlled studies suggested that blood type A was associated with a higher risk of lung cancer. In addition, the analysis confirmed that Caucasians with type O blood had a lower risk of lung cancer. However, prospective cohort studies have not been able to draw this conclusion. Different experimental designs may have had a notable influence on the results obtained.
具有某些ABO血型分类的患者患某些类型恶性肿瘤的风险增加。在本研究中，进行了一项荟萃分析，从循证医学的角度探讨ABO血型与肺癌风险之间的关联。检索了PubMed、Embase、Web of Science、Medline、中国知网、谷歌学术、Science Direct和万方数据库中的相关论文。使用Review Manger 5.4分析ABO血型与肺癌风险之间的关联。采用试验序贯分析（TSA）来确定荟萃分析的样本量是否充足。本文共纳入29项研究。病例对照研究结果显示，肺癌患者中A型血患者的比例显著高于健康个体[比值比（OR），1.10；95%置信区间（CI），1.02-1.19]。基于亚组分析，A型血在种族和对照来源（社会或医院）方面存在异质性。此外，确定O型血是白种人肺癌的保护因素（OR，0.92；95%CI，0.85-0.99）。TSA结果表明病例对照研究中有足够的参与者。总体而言，队列研究结果显示肺癌风险与血型之间存在弱关联，且差异无统计学意义。病例对照研究表明A型血与肺癌风险较高相关。此外，分析证实O型血的白种人患肺癌的风险较低。然而，前瞻性队列研究未能得出这一结论。不同的实验设计可能对所得结果产生了显著影响。
